| Name | EPOR |
| ID | P19235 |
| Role | substrate |
| Enzymatic Domains |
Fibronectin type-III 147-247 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | EPOR | Tyr456 | PPHLKYLyLVVSDSG | phosphorylation up-regulates activity | 12441334 | SIGNOR-251351 |
| PTPN1 | EPOR | – | dephosphorylation down-regulates activity | 14527337 | SIGNOR-276994 | |
| JAK2 | EPOR | Tyr504 | AEPLPPSyVACS | phosphorylation up-regulates activity | 12441334 | SIGNOR-251355 |
| JAK2 | EPOR | Tyr485 | GGLSDGPySNPYENS | phosphorylation up-regulates activity | 12441334 | SIGNOR-251353 |
| JAK2 | EPOR | Tyr426 | ASAASFEyTILDPSS | phosphorylation up-regulates activity | 12441334 | SIGNOR-251349 |
| JAK2 | EPOR | Tyr454 | PTPPHLKyLYLVVSD | phosphorylation up-regulates activity | 12441334 | SIGNOR-251350 |
| JAK2 | EPOR | Tyr368 | SEHAQDTyLVLDKWL | phosphorylation up-regulates activity | 12441334 | SIGNOR-251348 |
| JAK2 | EPOR | Tyr468 | DSGISTDySSGDSQG | phosphorylation up-regulates activity | 12441334 | SIGNOR-251352 |
| JAK2 | EPOR | Tyr489 | DGPYSNPyENSLIPA | phosphorylation up-regulates activity | 12441334 | SIGNOR-251354 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | EPOR PTyr456 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251351 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr504 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251355 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr485 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251353 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr426 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251349 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr454 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251350 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr368 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251348 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr468 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251352 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr489 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251354 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251351 |
| PTPN1 | dephosphorylation → down-regulates activity | EPOR | SIGNOR-276994 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251355 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251353 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251349 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251350 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251348 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251352 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251354 |