Entity Details

Name HK1
ID P19367
Role substrate
Enzymatic Domains
Hexokinase 1 16-458
PROSITE-ProRule
Hexokinase 2 464-906
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ULK1HK1Ser364TRLGVEPsDDDCVSVphosphorylation
up-regulates activity		27153534SIGNOR-274033
ULK1HK1Ser124NIVHGSGsQLFDHVAphosphorylation
up-regulates activity		27153534SIGNOR-274034
SRCHK1Tyr732YDRLVDEySLNAGKQphosphorylation
up-regulates activity		28054552SIGNOR-277335
ULK2HK1Ser364TRLGVEPsDDDCVSVphosphorylation
up-regulates activity		27153534SIGNOR-274041
ULK2HK1Ser124NIVHGSGsQLFDHVAphosphorylation
up-regulates activity		27153534SIGNOR-274042
SRCHK1Tyr732YDRLVDEySLNAGKQphosphorylation
down-regulates activity		28054552SIGNOR-278209
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ULK1phosphorylation
up-regulates
→
HK1
PSer364		phosphorylation
up-regulates
→		HK127153534SIGNOR-274033
ULK1phosphorylation
up-regulates
→
HK1
PSer124		phosphorylation
up-regulates
→		HK127153534SIGNOR-274034
SRCphosphorylation
up-regulates
→
HK1
PTyr732		phosphorylation
up-regulates
→		HK128054552SIGNOR-277335
ULK2phosphorylation
up-regulates
→
HK1
PSer364		phosphorylation
up-regulates
→		HK127153534SIGNOR-274041
ULK2phosphorylation
up-regulates
→
HK1
PSer124		phosphorylation
up-regulates
→		HK127153534SIGNOR-274042
SRCphosphorylation
up-regulates
→
HK1
PTyr732		phosphorylation
down-regulates
⊣		HK128054552SIGNOR-278209
Regulator Mechanism/Effect Target SIGNOR-ID
ULK1phosphorylation
→
up-regulates activity 		HK1SIGNOR-274033
ULK1phosphorylation
→
up-regulates activity 		HK1SIGNOR-274034
SRCphosphorylation
→
up-regulates activity 		HK1SIGNOR-277335
ULK2phosphorylation
→
up-regulates activity 		HK1SIGNOR-274041
ULK2phosphorylation
→
up-regulates activity 		HK1SIGNOR-274042
SRCphosphorylation
→
down-regulates activity 		HK1SIGNOR-278209