| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | TNNI3 | Thr129 | ITEIADLtQKIFDLR | phosphorylation unknown | 18986304 | SIGNOR-182049 |
| PRKCB | TNNI3 | Thr143 | RGKFKRPtLRRVRIS | phosphorylation down-regulates | 17010989 | SIGNOR-149957 |
| PRKCD | TNNI3 | Thr143 | RGKFKRPtLRRVRIS | phosphorylation down-regulates | 18550549 | SIGNOR-178888 |
| PRKCB | TNNI3 | Ser44 | KKSKISAsRKLQLKT | phosphorylation down-regulates | 15769444 | SIGNOR-134628 |
| PAK3 | TNNI3 | Ser150 | TLRRVRIsADAMMQA | phosphorylation unknown | 12242269 | SIGNOR-92990 |
| STK4 | TNNI3 | Thr51 | SRKLQLKtLLLQIAK | phosphorylation unknown | 18986304 | SIGNOR-182061 |
| PRKG1 | TNNI3 | Ser24 | APIRRRSsNYRAYAT | phosphorylation up-regulates activity | 15769444 | SIGNOR-134644 |
| PRKCA | TNNI3 | Ser39 | EPHAKKKsKISASRK | phosphorylation down-regulates activity | 11121119 | SIGNOR-249068 |
| PRKCB | TNNI3 | Ser42 | AKKKSKIsASRKLQL | phosphorylation down-regulates | 15769444 | SIGNOR-134624 |
| PRKG1 | TNNI3 | Ser23 | PAPIRRRsSNYRAYA | phosphorylation up-regulates activity | 15769444 | SIGNOR-134640 |
| PRKCA | TNNI3 | Ser23 | PAPIRRRsSNYRAYA | phosphorylation up-regulates activity | 11121119 | SIGNOR-249066 |
| PPP2CA | TNNI3 | Ser24 | APIRRRSsNYRAYAT | dephosphorylation down-regulates | 15769444 | SIGNOR-134601 |
| PRKCG | TNNI3 | Ser42 | AKKKSKIsASRKLQL | phosphorylation down-regulates | 15769444 | SIGNOR-134632 |
| PRKCA | TNNI3 | Ser42 | AKKKSKIsASRKLQL | phosphorylation down-regulates | 15769444 | SIGNOR-134613 |
| PRKCD | TNNI3 | Ser23 | PAPIRRRsSNYRAYA | phosphorylation up-regulates activity | 18550549 | SIGNOR-178880 |
| PRKCA | TNNI3 | Ser24 | APIRRRSsNYRAYAT | phosphorylation up-regulates activity | 11121119 | SIGNOR-249067 |
| PRKCA | TNNI3 | Ser44 | KKSKISAsRKLQLKT | phosphorylation down-regulates | 15769444 | SIGNOR-134617 |
| PRKCA | TNNI3 | Ser77 | GEKGRALsTRCQPLE | phosphorylation unknown | 2584239 | SIGNOR-248890 |
| PRKCG | TNNI3 | Ser44 | KKSKISAsRKLQLKT | phosphorylation down-regulates | 15769444 | SIGNOR-134636 |
| PRKACA | TNNI3 | Ser23 | PAPIRRRsSNYRAYA | phosphorylation up-regulates activity | 15769444 | SIGNOR-134605 |
| PAK3 | TNNI3 | Ser150 | TLRRVRIsADAMMQA | phosphorylation down-regulates | 15769444 | SIGNOR-134593 |
| PRKCD | TNNI3 | Thr143 | RGKFKRPtLRRVRIS | phosphorylation down-regulates | 24585778 | SIGNOR-204666 |
| PRKACA | TNNI3 | Ser24 | APIRRRSsNYRAYAT | phosphorylation up-regulates activity | 15769444 | SIGNOR-134609 |
| STK4 | TNNI3 | Thr31 | SNYRAYAtEPHAKKK | phosphorylation unknown | 18986304 | SIGNOR-182057 |
| PPP2CA | TNNI3 | Ser23 | PAPIRRRsSNYRAYA | dephosphorylation down-regulates | 15769444 | SIGNOR-134597 |
| PRKCA | TNNI3 | Ser166 | LGARAKEsLDLRAHL | phosphorylation down-regulates activity | 11121119 | SIGNOR-249069 |
| STK4 | TNNI3 | Thr143 | RGKFKRPtLRRVRIS | phosphorylation unknown | 18986304 | SIGNOR-182053 |
| PRKCD | TNNI3 | Ser24 | APIRRRSsNYRAYAT | phosphorylation up-regulates activity | 18550549 | SIGNOR-178884 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | phosphorylation up-regulates → | TNNI3 PThr129 | phosphorylation down-regulates ⊣ | TNNI3 | 18986304 | SIGNOR-182049 |
| PRKCB | phosphorylation up-regulates → | TNNI3 PThr143 | phosphorylation down-regulates ⊣ | TNNI3 | 17010989 | SIGNOR-149957 |
| PRKCD | phosphorylation up-regulates → | TNNI3 PThr143 | phosphorylation down-regulates ⊣ | TNNI3 | 18550549 | SIGNOR-178888 |
| PRKCB | phosphorylation up-regulates → | TNNI3 PSer44 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134628 |
| PAK3 | phosphorylation up-regulates → | TNNI3 PSer150 | phosphorylation down-regulates ⊣ | TNNI3 | 12242269 | SIGNOR-92990 |
| STK4 | phosphorylation up-regulates → | TNNI3 PThr51 | phosphorylation down-regulates ⊣ | TNNI3 | 18986304 | SIGNOR-182061 |
| PRKG1 | phosphorylation up-regulates → | TNNI3 PSer24 | phosphorylation up-regulates → | TNNI3 | 15769444 | SIGNOR-134644 |
| PRKCA | phosphorylation up-regulates → | TNNI3 PSer39 | phosphorylation down-regulates ⊣ | TNNI3 | 11121119 | SIGNOR-249068 |
| PRKCB | phosphorylation up-regulates → | TNNI3 PSer42 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134624 |
| PRKG1 | phosphorylation up-regulates → | TNNI3 PSer23 | phosphorylation up-regulates → | TNNI3 | 15769444 | SIGNOR-134640 |
| PRKCA | phosphorylation up-regulates → | TNNI3 PSer23 | phosphorylation up-regulates → | TNNI3 | 11121119 | SIGNOR-249066 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TNNI3 PSer24 | dephosphorylation up-regulates → | TNNI3 | 15769444 | SIGNOR-134601 |
| PRKCG | phosphorylation up-regulates → | TNNI3 PSer42 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134632 |
| PRKCA | phosphorylation up-regulates → | TNNI3 PSer42 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134613 |
| PRKCD | phosphorylation up-regulates → | TNNI3 PSer23 | phosphorylation up-regulates → | TNNI3 | 18550549 | SIGNOR-178880 |
| PRKCA | phosphorylation up-regulates → | TNNI3 PSer24 | phosphorylation up-regulates → | TNNI3 | 11121119 | SIGNOR-249067 |
| PRKCA | phosphorylation up-regulates → | TNNI3 PSer44 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134617 |
| PRKCA | phosphorylation up-regulates → | TNNI3 PSer77 | phosphorylation down-regulates ⊣ | TNNI3 | 2584239 | SIGNOR-248890 |
| PRKCG | phosphorylation up-regulates → | TNNI3 PSer44 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134636 |
| PRKACA | phosphorylation up-regulates → | TNNI3 PSer23 | phosphorylation up-regulates → | TNNI3 | 15769444 | SIGNOR-134605 |
| PAK3 | phosphorylation up-regulates → | TNNI3 PSer150 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134593 |
| PRKCD | phosphorylation up-regulates → | TNNI3 PThr143 | phosphorylation down-regulates ⊣ | TNNI3 | 24585778 | SIGNOR-204666 |
| PRKACA | phosphorylation up-regulates → | TNNI3 PSer24 | phosphorylation up-regulates → | TNNI3 | 15769444 | SIGNOR-134609 |
| STK4 | phosphorylation up-regulates → | TNNI3 PThr31 | phosphorylation down-regulates ⊣ | TNNI3 | 18986304 | SIGNOR-182057 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TNNI3 PSer23 | dephosphorylation up-regulates → | TNNI3 | 15769444 | SIGNOR-134597 |
| PRKCA | phosphorylation up-regulates → | TNNI3 PSer166 | phosphorylation down-regulates ⊣ | TNNI3 | 11121119 | SIGNOR-249069 |
| STK4 | phosphorylation up-regulates → | TNNI3 PThr143 | phosphorylation down-regulates ⊣ | TNNI3 | 18986304 | SIGNOR-182053 |
| PRKCD | phosphorylation up-regulates → | TNNI3 PSer24 | phosphorylation up-regulates → | TNNI3 | 18550549 | SIGNOR-178884 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK4 | phosphorylation → unknown | TNNI3 | SIGNOR-182049 |
| PRKCB | phosphorylation down-regulates | TNNI3 | SIGNOR-149957 |
| PRKCD | phosphorylation down-regulates | TNNI3 | SIGNOR-178888 |
| PRKCB | phosphorylation down-regulates | TNNI3 | SIGNOR-134628 |
| PAK3 | phosphorylation → unknown | TNNI3 | SIGNOR-92990 |
| STK4 | phosphorylation → unknown | TNNI3 | SIGNOR-182061 |
| PRKG1 | phosphorylation → up-regulates activity | TNNI3 | SIGNOR-134644 |
| PRKCA | phosphorylation → down-regulates activity | TNNI3 | SIGNOR-249068 |
| PRKCB | phosphorylation down-regulates | TNNI3 | SIGNOR-134624 |
| PRKG1 | phosphorylation → up-regulates activity | TNNI3 | SIGNOR-134640 |
| PRKCA | phosphorylation → up-regulates activity | TNNI3 | SIGNOR-249066 |
| PPP2CA | dephosphorylation down-regulates | TNNI3 | SIGNOR-134601 |
| PRKCG | phosphorylation down-regulates | TNNI3 | SIGNOR-134632 |
| PRKCA | phosphorylation down-regulates | TNNI3 | SIGNOR-134613 |
| PRKCD | phosphorylation → up-regulates activity | TNNI3 | SIGNOR-178880 |
| PRKCA | phosphorylation → up-regulates activity | TNNI3 | SIGNOR-249067 |
| PRKCA | phosphorylation down-regulates | TNNI3 | SIGNOR-134617 |
| PRKCA | phosphorylation → unknown | TNNI3 | SIGNOR-248890 |
| PRKCG | phosphorylation down-regulates | TNNI3 | SIGNOR-134636 |
| PRKACA | phosphorylation → up-regulates activity | TNNI3 | SIGNOR-134605 |
| PAK3 | phosphorylation down-regulates | TNNI3 | SIGNOR-134593 |
| PRKCD | phosphorylation down-regulates | TNNI3 | SIGNOR-204666 |
| PRKACA | phosphorylation → up-regulates activity | TNNI3 | SIGNOR-134609 |
| STK4 | phosphorylation → unknown | TNNI3 | SIGNOR-182057 |
| PPP2CA | dephosphorylation down-regulates | TNNI3 | SIGNOR-134597 |
| PRKCA | phosphorylation → down-regulates activity | TNNI3 | SIGNOR-249069 |
| STK4 | phosphorylation → unknown | TNNI3 | SIGNOR-182053 |
| PRKCD | phosphorylation → up-regulates activity | TNNI3 | SIGNOR-178884 |
