| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | TNNI3 | Ser42 | AKKKSKIsASRKLQL | phosphorylation down-regulates | 15769444 | SIGNOR-134624 |
| PRKCG | TNNI3 | Ser42 | AKKKSKIsASRKLQL | phosphorylation down-regulates | 15769444 | SIGNOR-134632 |
| PRKCA | TNNI3 | Ser42 | AKKKSKIsASRKLQL | phosphorylation down-regulates | 15769444 | SIGNOR-134613 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | phosphorylation up-regulates → | TNNI3 PSer42 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134624 |
| PRKCG | phosphorylation up-regulates → | TNNI3 PSer42 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134632 |
| PRKCA | phosphorylation up-regulates → | TNNI3 PSer42 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134613 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCB | phosphorylation down-regulates | TNNI3 | SIGNOR-134624 |
| PRKCG | phosphorylation down-regulates | TNNI3 | SIGNOR-134632 |
| PRKCA | phosphorylation down-regulates | TNNI3 | SIGNOR-134613 |
