Entity Details

Name ERCC3
ID P19447
Role substrate
Enzymatic Domains
Helicase ATP-binding 327-488
PROSITE-ProRule
Helicase C-terminal 542-702
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK7ERCC3Ser90HIFLEAFsPVYKYAQphosphorylation
down-regulates quantity by destabilization		30762924SIGNOR-277433
CSNK2A1ERCC3Ser751FGTMSSMsGADDTVYphosphorylation
down-regulates activity		15549133SIGNOR-276013
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK7phosphorylation
up-regulates
→
ERCC3
PSer90		phosphorylation
down-regulates
⊣		ERCC330762924SIGNOR-277433
CSNK2A1phosphorylation
up-regulates
→
ERCC3
PSer751		phosphorylation
down-regulates
⊣		ERCC315549133SIGNOR-276013
Regulator Mechanism/Effect Target SIGNOR-ID
CDK7phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERCC3SIGNOR-277433
CSNK2A1phosphorylation
→
down-regulates activity 		ERCC3SIGNOR-276013