| Name | EIF2AK2 |
| ID | P19525 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 267-538 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EIF2AK2 | PRKRA | – | phosphorylation up-regulates activity | 19580324 | SIGNOR-280003 | |
| EIF2AK2 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 10348343 | SIGNOR-68033 |
| EIF2AK2 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates | 16179259 | SIGNOR-140656 |
| EIF2AK2 | EIF2S1 | – | phosphorylation down-regulates activity | 31226023 | SIGNOR-260168 | |
| EIF2AK2 | CDK1 | Tyr4 | yTKIEKIG | phosphorylation down-regulates | 20395957 | SIGNOR-164809 |
| EIF2AK2 | MAPT | – | phosphorylation up-regulates quantity | 32716602 | SIGNOR-279735 | |
| EIF2AK2 | NCK1 | – | phosphorylation down-regulates activity | 18835251 | SIGNOR-279039 | |
| EIF2AK2 | EIF2AK2 | Ser242 | NQRKAKRsLAPRFDL | phosphorylation up-regulates | 11152499 | SIGNOR-85765 |
| EIF2AK2 | EIF2AK2 | Ser83 | NKEKKAVsPLLLTTT | phosphorylation up-regulates | 11152499 | SIGNOR-85769 |
| EIF2AK2 | EIF2AK2 | Thr255 | DLPDMKEtKYTVDKR | phosphorylation up-regulates | 11152499 | SIGNOR-85773 |
| EIF2AK2 | EIF2AK2 | Thr258 | DMKETKYtVDKRFGM | phosphorylation up-regulates | 11152499 | SIGNOR-85777 |
| EIF2AK2 | EIF2AK2 | Thr88 | AVSPLLLtTTNSSEG | phosphorylation up-regulates | 11152499 | SIGNOR-85781 |
| EIF2AK2 | EIF2AK2 | Thr89 | VSPLLLTtTNSSEGL | phosphorylation up-regulates | 11152499 | SIGNOR-85785 |
| EIF2AK2 | EIF2AK2 | Thr90 | SPLLLTTtNSSEGLS | phosphorylation up-regulates | 11152499 | SIGNOR-85789 |
| EIF2AK2 | EIF2AK2 | Thr446 | LKNDGKRtRSKGTLR | phosphorylation up-regulates activity | 11337501 | SIGNOR-251110 |
| EIF2AK2 | EIF2AK2 | Thr451 | KRTRSKGtLRYMSPE | phosphorylation up-regulates activity | 11337501 | SIGNOR-107511 |
| EIF2AK2 | EIF2AK2 | Tyr101 | EGLSMGNyIGLINRI | phosphorylation up-regulates activity | 16373505 | SIGNOR-260782 |
| EIF2AK2 | EIF2AK2 | Tyr101 | EGLSMGNyIGLINRI | phosphorylation up-regulates activity | 16373505 | SIGNOR-251112 |
| EIF2AK2 | EIF2AK2 | Tyr162 | QLAAKLAyLQILSEE | phosphorylation up-regulates activity | 16373505 | SIGNOR-251113 |
| EIF2AK2 | EIF2AK2 | Tyr162 | QLAAKLAyLQILSEE | phosphorylation up-regulates activity | 16373505 | SIGNOR-260783 |
| EIF2AK2 | EIF2AK2 | Tyr293 | HRIDGKTyVIKRVKY | phosphorylation up-regulates activity | 16373505 | SIGNOR-251114 |
| EIF2AK2 | EIF2AK2 | Tyr293 | HRIDGKTyVIKRVKY | phosphorylation up-regulates activity | 16373505 | SIGNOR-260784 |
| EIF2AK2 | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates quantity by destabilization | 10723127 | SIGNOR-249335 |
| EIF2AK2 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 20685959 | SIGNOR-278310 |
| EIF2AK2 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 25360179 | SIGNOR-279612 |
| EIF2AK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 25360179 | SIGNOR-279613 |
| EIF2AK2 | MAP2K6 | – | phosphorylation up-regulates activity | 15229216 | SIGNOR-279707 | |
| EIF2AK2 | PPP2R5A | Ser28 | VDGFTRKsVRKAQRQ | phosphorylation up-regulates | 18957415 | SIGNOR-181793 |
| EIF2AK2 | KDM4C | Ser918 | MFDDGSFsRDTFPED | phosphorylation down-regulates quantity by destabilization | 31888886 | SIGNOR-277497 |
| EIF2AK2 | SPHK1 | Ser225 | VGSKTPAsPVVVQQG | phosphorylation up-regulates activity | 32801355 | SIGNOR-278514 |
| EIF2AK2 | PA2G4 | – | phosphorylation up-regulates activity | 16631606 | SIGNOR-279170 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EIF2AK2 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 10348343 | SIGNOR-68033 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 16179259 | SIGNOR-140656 |
| EIF2AK2 | phosphorylation up-regulates → | CDK1 PTyr4 | phosphorylation down-regulates ⊣ | CDK1 | 20395957 | SIGNOR-164809 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PSer242 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85765 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PSer83 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85769 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr255 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85773 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr258 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85777 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr88 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85781 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr89 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85785 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr90 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85789 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr446 | phosphorylation up-regulates → | EIF2AK2 | 11337501 | SIGNOR-251110 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr451 | phosphorylation up-regulates → | EIF2AK2 | 11337501 | SIGNOR-107511 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr101 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-260782 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr101 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-251112 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr162 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-251113 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr162 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-260783 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr293 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-251114 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr293 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-260784 |
| EIF2AK2 | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 10723127 | SIGNOR-249335 |
| EIF2AK2 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 20685959 | SIGNOR-278310 |
| EIF2AK2 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 25360179 | SIGNOR-279612 |
| EIF2AK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 25360179 | SIGNOR-279613 |
| EIF2AK2 | phosphorylation up-regulates → | PPP2R5A PSer28 | phosphorylation up-regulates → | PPP2R5A | 18957415 | SIGNOR-181793 |
| EIF2AK2 | phosphorylation up-regulates → | KDM4C PSer918 | phosphorylation down-regulates ⊣ | KDM4C | 31888886 | SIGNOR-277497 |
| EIF2AK2 | phosphorylation up-regulates → | SPHK1 PSer225 | phosphorylation up-regulates → | SPHK1 | 32801355 | SIGNOR-278514 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EIF2AK2 | phosphorylation → up-regulates activity | PRKRA | SIGNOR-280003 |
| EIF2AK2 | phosphorylation → up-regulates | TP53 | SIGNOR-68033 |
| EIF2AK2 | phosphorylation down-regulates | EIF2S1 | SIGNOR-140656 |
| EIF2AK2 | phosphorylation → down-regulates activity | EIF2S1 | SIGNOR-260168 |
| EIF2AK2 | phosphorylation down-regulates | CDK1 | SIGNOR-164809 |
| EIF2AK2 | phosphorylation → up-regulates quantity | MAPT | SIGNOR-279735 |
| EIF2AK2 | phosphorylation → down-regulates activity | NCK1 | SIGNOR-279039 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85765 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85769 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85773 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85777 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85781 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85785 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85789 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-251110 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-107511 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-260782 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-251112 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-251113 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-260783 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-251114 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-260784 |
| EIF2AK2 | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249335 |
| EIF2AK2 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-278310 |
| EIF2AK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279612 |
| EIF2AK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279613 |
| EIF2AK2 | phosphorylation → up-regulates activity | MAP2K6 | SIGNOR-279707 |
| EIF2AK2 | phosphorylation → up-regulates | PPP2R5A | SIGNOR-181793 |
| EIF2AK2 | phosphorylation down-regulates quantity by destabilization | KDM4C | SIGNOR-277497 |
| EIF2AK2 | phosphorylation → up-regulates activity | SPHK1 | SIGNOR-278514 |
| EIF2AK2 | phosphorylation → up-regulates activity | PA2G4 | SIGNOR-279170 |