| Name | EIF2AK2 |
| ID | P19525 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 267-538 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EIF2AK2 | EIF2AK2 | Tyr101 | EGLSMGNyIGLINRI | phosphorylation up-regulates activity | 16373505 | SIGNOR-251112 |
| EIF2AK2 | EIF2AK2 | Thr88 | AVSPLLLtTTNSSEG | phosphorylation up-regulates | 11152499 | SIGNOR-85781 |
| EIF2AK2 | EIF2AK2 | Ser83 | NKEKKAVsPLLLTTT | phosphorylation up-regulates | 11152499 | SIGNOR-85769 |
| EIF2AK2 | EIF2AK2 | Tyr293 | HRIDGKTyVIKRVKY | phosphorylation up-regulates activity | 16373505 | SIGNOR-260784 |
| EIF2AK2 | EIF2AK2 | Thr258 | DMKETKYtVDKRFGM | phosphorylation up-regulates | 11152499 | SIGNOR-85777 |
| EIF2AK2 | EIF2AK2 | Thr89 | VSPLLLTtTNSSEGL | phosphorylation up-regulates | 11152499 | SIGNOR-85785 |
| EIF2AK2 | EIF2AK2 | Thr451 | KRTRSKGtLRYMSPE | phosphorylation up-regulates activity | 11337501 | SIGNOR-107511 |
| EIF2AK2 | EIF2AK2 | Tyr162 | QLAAKLAyLQILSEE | phosphorylation up-regulates activity | 16373505 | SIGNOR-251113 |
| EIF2AK2 | EIF2AK2 | Thr255 | DLPDMKEtKYTVDKR | phosphorylation up-regulates | 11152499 | SIGNOR-85773 |
| EIF2AK2 | EIF2AK2 | Tyr101 | EGLSMGNyIGLINRI | phosphorylation up-regulates activity | 16373505 | SIGNOR-260782 |
| EIF2AK2 | EIF2AK2 | Ser242 | NQRKAKRsLAPRFDL | phosphorylation up-regulates | 11152499 | SIGNOR-85765 |
| EIF2AK2 | EIF2AK2 | Tyr293 | HRIDGKTyVIKRVKY | phosphorylation up-regulates activity | 16373505 | SIGNOR-251114 |
| EIF2AK2 | EIF2AK2 | Thr446 | LKNDGKRtRSKGTLR | phosphorylation up-regulates activity | 11337501 | SIGNOR-251110 |
| MAPK1 | EIF2AK2 | Thr451 | KRTRSKGtLRYMSPE | phosphorylation up-regulates | 9528799 | SIGNOR-56337 |
| EIF2AK2 | EIF2AK2 | Tyr162 | QLAAKLAyLQILSEE | phosphorylation up-regulates activity | 16373505 | SIGNOR-260783 |
| EIF2AK2 | EIF2AK2 | Thr90 | SPLLLTTtNSSEGLS | phosphorylation up-regulates | 11152499 | SIGNOR-85789 |
| RPS6KA3 | EIF2AK2 | Thr451 | KRTRSKGtLRYMSPE | phosphorylation up-regulates | 17404396 | SIGNOR-154183 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr101 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-251112 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr88 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85781 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PSer83 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85769 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr293 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-260784 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr258 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85777 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr89 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85785 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr451 | phosphorylation up-regulates → | EIF2AK2 | 11337501 | SIGNOR-107511 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr162 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-251113 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr255 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85773 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr101 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-260782 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PSer242 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85765 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr293 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-251114 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr446 | phosphorylation up-regulates → | EIF2AK2 | 11337501 | SIGNOR-251110 |
| MAPK1 | phosphorylation up-regulates → | EIF2AK2 PThr451 | phosphorylation up-regulates → | EIF2AK2 | 9528799 | SIGNOR-56337 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PTyr162 | phosphorylation up-regulates → | EIF2AK2 | 16373505 | SIGNOR-260783 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr90 | phosphorylation up-regulates → | EIF2AK2 | 11152499 | SIGNOR-85789 |
| RPS6KA3 | phosphorylation up-regulates → | EIF2AK2 PThr451 | phosphorylation up-regulates → | EIF2AK2 | 17404396 | SIGNOR-154183 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-251112 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85781 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85769 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-260784 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85777 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85785 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-107511 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-251113 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85773 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-260782 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85765 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-251114 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-251110 |
| MAPK1 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-56337 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-260783 |
| EIF2AK2 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-85789 |
| RPS6KA3 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-154183 |