| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA3 | EIF2AK2 | Thr451 | KRTRSKGtLRYMSPE | phosphorylation up-regulates | 17404396 | SIGNOR-154183 |
| EIF2AK2 | EIF2AK2 | Thr451 | KRTRSKGtLRYMSPE | phosphorylation up-regulates activity | 11337501 | SIGNOR-107511 |
| MAPK1 | EIF2AK2 | Thr451 | KRTRSKGtLRYMSPE | phosphorylation up-regulates | 9528799 | SIGNOR-56337 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA3 | phosphorylation up-regulates → | EIF2AK2 PThr451 | phosphorylation up-regulates → | EIF2AK2 | 17404396 | SIGNOR-154183 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2AK2 PThr451 | phosphorylation up-regulates → | EIF2AK2 | 11337501 | SIGNOR-107511 |
| MAPK1 | phosphorylation up-regulates → | EIF2AK2 PThr451 | phosphorylation up-regulates → | EIF2AK2 | 9528799 | SIGNOR-56337 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA3 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-154183 |
| EIF2AK2 | phosphorylation → up-regulates activity | EIF2AK2 | SIGNOR-107511 |
| MAPK1 | phosphorylation → up-regulates | EIF2AK2 | SIGNOR-56337 |
