| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | WT1 | Ser365 | KDCERRFsRSDQLKR | phosphorylation down-regulates | 9366517 | SIGNOR-53172 |
| PRKACA | WT1 | Ser393 | KTCQRKFsRSDHLKT | phosphorylation down-regulates | 9366517 | SIGNOR-53176 |
| GSK3B | WT1 | Ser208 | GCHTPTDsCTGSQAL | phosphorylation down-regulates quantity by destabilization | 33184107 | SIGNOR-277540 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | WT1 PSer365 | phosphorylation down-regulates ⊣ | WT1 | 9366517 | SIGNOR-53172 |
| PRKACA | phosphorylation up-regulates → | WT1 PSer393 | phosphorylation down-regulates ⊣ | WT1 | 9366517 | SIGNOR-53176 |
| GSK3B | phosphorylation up-regulates → | WT1 PSer208 | phosphorylation down-regulates ⊣ | WT1 | 33184107 | SIGNOR-277540 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation down-regulates | WT1 | SIGNOR-53172 |
| PRKACA | phosphorylation down-regulates | WT1 | SIGNOR-53176 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | WT1 | SIGNOR-277540 |
