| Name | CDK11B |
| ID | P21127 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 438-723 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK7 | CDK11B | Thr595 | GSPLKAYtPVVVTLW | phosphorylation up-regulates activity | 16327805 | SIGNOR-245871 |
| CDK11A | CDK11B | Thr726 | KHEYFREtPLPIDPS | phosphorylation up-regulates | 21078675 | SIGNOR-169628 |
| CHEK2 | CDK11B | – | phosphorylation up-regulates activity | 23178491 | SIGNOR-279458 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK7 | phosphorylation up-regulates → | CDK11B PThr595 | phosphorylation up-regulates → | CDK11B | 16327805 | SIGNOR-245871 |
| CDK11A | phosphorylation up-regulates → | CDK11B PThr726 | phosphorylation up-regulates → | CDK11B | 21078675 | SIGNOR-169628 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK7 | phosphorylation → up-regulates activity | CDK11B | SIGNOR-245871 |
| CDK11A | phosphorylation → up-regulates | CDK11B | SIGNOR-169628 |
| CHEK2 | phosphorylation → up-regulates activity | CDK11B | SIGNOR-279458 |