| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | FPR1 | Thr334 | DSTQTSDtATNSTLP | phosphorylation down-regulates activity | 7836371 | SIGNOR-251451 |
| GRK2 | FPR1 | Thr336 | TQTSDTAtNSTLPSA | phosphorylation down-regulates activity | 7836371 | SIGNOR-249686 |
| GRK2 | FPR1 | Thr329 | RALTEDStQTSDTAT | phosphorylation down-regulates activity | 7836371 | SIGNOR-249664 |
| GRK2 | FPR1 | Thr339 | SDTATNStLPSAEVE | phosphorylation down-regulates activity | 7836371 | SIGNOR-251452 |
| GRK2 | FPR1 | Ser332 | TEDSTQTsDTATNST | phosphorylation down-regulates activity | 7836371 | SIGNOR-249680 |
| GRK2 | FPR1 | Ser328 | ERALTEDsTQTSDTA | phosphorylation down-regulates activity | 7836371 | SIGNOR-247763 |
| GRK2 | FPR1 | Thr331 | LTEDSTQtSDTATNS | phosphorylation down-regulates activity | 7836371 | SIGNOR-249676 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | phosphorylation up-regulates → | FPR1 PThr334 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-251451 |
| GRK2 | phosphorylation up-regulates → | FPR1 PThr336 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-249686 |
| GRK2 | phosphorylation up-regulates → | FPR1 PThr329 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-249664 |
| GRK2 | phosphorylation up-regulates → | FPR1 PThr339 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-251452 |
| GRK2 | phosphorylation up-regulates → | FPR1 PSer332 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-249680 |
| GRK2 | phosphorylation up-regulates → | FPR1 PSer328 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-247763 |
| GRK2 | phosphorylation up-regulates → | FPR1 PThr331 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-249676 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-251451 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-249686 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-249664 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-251452 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-249680 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-247763 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-249676 |
