| Name | FGFR2 |
| ID | P21802 |
| Role | kinase |
| Enzymatic Domains |
Ig-like C2-type 1 25-125
Ig-like C2-type 2 154-247
Ig-like C2-type 3 256-358
Protein kinase 481-770 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR2 | FGFR2 | Tyr769 | TLTTNEEyLDLSQPL | phosphorylation up-regulates activity | 15629145 | SIGNOR-276026 |
| FGFR2 | PTEN | Tyr240 | RREDKFMyFEFPQPL | phosphorylation unknown | 22891331 | SIGNOR-191793 |
| FGFR2 | GRB2 | – | phosphorylation up-regulates | 22726438 | SIGNOR-197980 | |
| FGFR2 | GLO1 | Tyr136 | GIAVPDVySACKRFE | phosphorylation up-regulates activity | 34838714 | SIGNOR-276184 |
| FGFR2 | FRS2 | – | phosphorylation up-regulates activity | 9182757 | SIGNOR-236950 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR2 | phosphorylation up-regulates → | FGFR2 PTyr769 | phosphorylation up-regulates → | FGFR2 | 15629145 | SIGNOR-276026 |
| FGFR2 | phosphorylation up-regulates → | PTEN PTyr240 | phosphorylation down-regulates ⊣ | PTEN | 22891331 | SIGNOR-191793 |
| FGFR2 | phosphorylation up-regulates → | GLO1 PTyr136 | phosphorylation up-regulates → | GLO1 | 34838714 | SIGNOR-276184 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FGFR2 | phosphorylation → up-regulates activity | FGFR2 | SIGNOR-276026 |
| FGFR2 | phosphorylation → unknown | PTEN | SIGNOR-191793 |
| FGFR2 | phosphorylation → up-regulates | GRB2 | SIGNOR-197980 |
| FGFR2 | phosphorylation → up-regulates activity | GLO1 | SIGNOR-276184 |
| FGFR2 | phosphorylation → up-regulates activity | FRS2 | SIGNOR-236950 |