Entity Details

Name FGFR2
ID P21802
Role substrate
Enzymatic Domains
Ig-like C2-type 1 25-125
Ig-like C2-type 2 154-247
Ig-like C2-type 3 256-358
Protein kinase 481-770
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
FGFR2FGFR2Tyr769TLTTNEEyLDLSQPLphosphorylation
up-regulates activity		15629145SIGNOR-276026
PTPN11FGFR2–dephosphorylation
down-regulates activity		23420874SIGNOR-277030
PRKCEFGFR2Ser782PLEQYSPsYPDTRSSphosphorylation
up-regulates		23564461SIGNOR-201675
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
FGFR2phosphorylation
up-regulates
→
FGFR2
PTyr769		phosphorylation
up-regulates
→		FGFR215629145SIGNOR-276026
PRKCEphosphorylation
up-regulates
→
FGFR2
PSer782		phosphorylation
up-regulates
→		FGFR223564461SIGNOR-201675
Regulator Mechanism/Effect Target SIGNOR-ID
FGFR2phosphorylation
→
up-regulates activity 		FGFR2SIGNOR-276026
PTPN11dephosphorylation
→
down-regulates activity 		FGFR2SIGNOR-277030
PRKCEphosphorylation
→
up-regulates 		FGFR2SIGNOR-201675