| Name | RYR1 |
| ID | P21817 |
| Role | substrate |
| Enzymatic Domains |
MIR 1 97-152 PROSITE-ProRule
MIR 2 159-204 PROSITE-ProRule
MIR 3 210-264 PROSITE-ProRule
MIR 4 270-327 PROSITE-ProRule
MIR 5 335-392 PROSITE-ProRule
B30.2/SPRY 1 581-797 PROSITE-ProRule
B30.2/SPRY 2 1013-1208 PROSITE-ProRule
B30.2/SPRY 3 1356-1570 PROSITE-ProRule
EF-hand 4074-4102 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2G | RYR1 | Ser2843 | KKKTRKIsQSAQTYD | phosphorylation unknown | 8380342 | SIGNOR-250704 |
| PRKACA | RYR1 | Ser2843 | KKKTRKIsQSAQTYD | phosphorylation up-regulates activity | 14532276 | SIGNOR-250078 |
| PRKG1 | RYR1 | Ser2843 | KKKTRKIsQSAQTYD | phosphorylation unknown | 8380342 | SIGNOR-248918 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2G | phosphorylation up-regulates → | RYR1 PSer2843 | phosphorylation down-regulates ⊣ | RYR1 | 8380342 | SIGNOR-250704 |
| PRKACA | phosphorylation up-regulates → | RYR1 PSer2843 | phosphorylation up-regulates → | RYR1 | 14532276 | SIGNOR-250078 |
| PRKG1 | phosphorylation up-regulates → | RYR1 PSer2843 | phosphorylation down-regulates ⊣ | RYR1 | 8380342 | SIGNOR-248918 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2G | phosphorylation → unknown | RYR1 | SIGNOR-250704 |
| PRKACA | phosphorylation → up-regulates activity | RYR1 | SIGNOR-250078 |
| PRKG1 | phosphorylation → unknown | RYR1 | SIGNOR-248918 |