| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2G | RYR1 | Ser2843 | KKKTRKIsQSAQTYD | phosphorylation unknown | 8380342 | SIGNOR-250704 |
| PRKACA | RYR1 | Ser2843 | KKKTRKIsQSAQTYD | phosphorylation up-regulates activity | 14532276 | SIGNOR-250078 |
| PRKG1 | RYR1 | Ser2843 | KKKTRKIsQSAQTYD | phosphorylation unknown | 8380342 | SIGNOR-248918 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2G | phosphorylation up-regulates → | RYR1 PSer2843 | phosphorylation down-regulates ⊣ | RYR1 | 8380342 | SIGNOR-250704 |
| PRKACA | phosphorylation up-regulates → | RYR1 PSer2843 | phosphorylation up-regulates → | RYR1 | 14532276 | SIGNOR-250078 |
| PRKG1 | phosphorylation up-regulates → | RYR1 PSer2843 | phosphorylation down-regulates ⊣ | RYR1 | 8380342 | SIGNOR-248918 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2G | phosphorylation → unknown | RYR1 | SIGNOR-250704 |
| PRKACA | phosphorylation → up-regulates activity | RYR1 | SIGNOR-250078 |
| PRKG1 | phosphorylation → unknown | RYR1 | SIGNOR-248918 |
