Entity Details

Name ERBB3
ID P21860
Role substrate
Enzymatic Domains
Protein kinase 709-966
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK5ERBB3Ser1123RSRSRSRsPRPRGDSphosphorylation
up-regulates activity		12824184SIGNOR-250663
ROR1ERBB3–phosphorylation
up-regulates activity		22439932SIGNOR-279279
ERBB2ERBB3–phosphorylation
up-regulates activity		23912457SIGNOR-278200
EGFRERBB3Tyr1289CPASEQGyEEMRAFQphosphorylation
up-regulates		7929151SIGNOR-34752
CDK5ERBB3Thr873LLYSEAKtPIKWMALphosphorylation
up-regulates activity		12824184SIGNOR-250664
EGFRERBB3Tyr1276GGGPGGDyAAMGACPphosphorylation
up-regulates		7929151SIGNOR-34748
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK5phosphorylation
up-regulates
→
ERBB3
PSer1123		phosphorylation
up-regulates
→		ERBB312824184SIGNOR-250663
EGFRphosphorylation
up-regulates
→
ERBB3
PTyr1289		phosphorylation
up-regulates
→		ERBB37929151SIGNOR-34752
CDK5phosphorylation
up-regulates
→
ERBB3
PThr873		phosphorylation
up-regulates
→		ERBB312824184SIGNOR-250664
EGFRphosphorylation
up-regulates
→
ERBB3
PTyr1276		phosphorylation
up-regulates
→		ERBB37929151SIGNOR-34748
Regulator Mechanism/Effect Target SIGNOR-ID
CDK5phosphorylation
→
up-regulates activity 		ERBB3SIGNOR-250663
ROR1phosphorylation
→
up-regulates activity 		ERBB3SIGNOR-279279
ERBB2phosphorylation
→
up-regulates activity 		ERBB3SIGNOR-278200
EGFRphosphorylation
→
up-regulates 		ERBB3SIGNOR-34752
CDK5phosphorylation
→
up-regulates activity 		ERBB3SIGNOR-250664
EGFRphosphorylation
→
up-regulates 		ERBB3SIGNOR-34748