| Name | ERBB3 |
| ID | P21860 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 709-966 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | ERBB3 | Tyr1276 | GGGPGGDyAAMGACP | phosphorylation up-regulates | 7929151 | SIGNOR-34748 |
| EGFR | ERBB3 | Tyr1289 | CPASEQGyEEMRAFQ | phosphorylation up-regulates | 7929151 | SIGNOR-34752 |
| CDK5 | ERBB3 | Thr873 | LLYSEAKtPIKWMAL | phosphorylation up-regulates activity | 12824184 | SIGNOR-250664 |
| CDK5 | ERBB3 | Ser1123 | RSRSRSRsPRPRGDS | phosphorylation up-regulates activity | 12824184 | SIGNOR-250663 |
| ERBB2 | ERBB3 | – | phosphorylation up-regulates activity | 23912457 | SIGNOR-278200 | |
| ROR1 | ERBB3 | – | phosphorylation up-regulates activity | 22439932 | SIGNOR-279279 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | ERBB3 PTyr1276 | phosphorylation up-regulates → | ERBB3 | 7929151 | SIGNOR-34748 |
| EGFR | phosphorylation up-regulates → | ERBB3 PTyr1289 | phosphorylation up-regulates → | ERBB3 | 7929151 | SIGNOR-34752 |
| CDK5 | phosphorylation up-regulates → | ERBB3 PThr873 | phosphorylation up-regulates → | ERBB3 | 12824184 | SIGNOR-250664 |
| CDK5 | phosphorylation up-regulates → | ERBB3 PSer1123 | phosphorylation up-regulates → | ERBB3 | 12824184 | SIGNOR-250663 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → up-regulates | ERBB3 | SIGNOR-34748 |
| EGFR | phosphorylation → up-regulates | ERBB3 | SIGNOR-34752 |
| CDK5 | phosphorylation → up-regulates activity | ERBB3 | SIGNOR-250664 |
| CDK5 | phosphorylation → up-regulates activity | ERBB3 | SIGNOR-250663 |
| ERBB2 | phosphorylation → up-regulates activity | ERBB3 | SIGNOR-278200 |
| ROR1 | phosphorylation → up-regulates activity | ERBB3 | SIGNOR-279279 |