| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NME2 | KCNN4 | His358 | FRQVRLKhRKLREQV | phosphorylation up-regulates | 17157250 | SIGNOR-151130 |
| NME2 | KCNN4 | His358 | FRQVRLKhRKLREQV | phosphorylation up-regulates | 18796614 | SIGNOR-181083 |
| NME2 | NME2 | His118 | QVGRNIIhGSDSVKS | phosphorylation up-regulates activity | 8132589 | SIGNOR-250304 |
| NME2 | NME2 | Ser44 | AMKFLRAsEEHLKQH | phosphorylation up-regulates activity | 8245015 | SIGNOR-250201 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NME2 | phosphorylation up-regulates → | KCNN4 PHis358 | phosphorylation up-regulates → | KCNN4 | 17157250 | SIGNOR-151130 |
| NME2 | phosphorylation up-regulates → | KCNN4 PHis358 | phosphorylation up-regulates → | KCNN4 | 18796614 | SIGNOR-181083 |
| NME2 | phosphorylation up-regulates → | NME2 PHis118 | phosphorylation up-regulates → | NME2 | 8132589 | SIGNOR-250304 |
| NME2 | phosphorylation up-regulates → | NME2 PSer44 | phosphorylation up-regulates → | NME2 | 8245015 | SIGNOR-250201 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NME2 | phosphorylation → up-regulates | KCNN4 | SIGNOR-151130 |
| NME2 | phosphorylation → up-regulates | KCNN4 | SIGNOR-181083 |
| NME2 | phosphorylation → up-regulates activity | NME2 | SIGNOR-250304 |
| NME2 | phosphorylation → up-regulates activity | NME2 | SIGNOR-250201 |
