| Name | FGFR4 |
| ID | P22455 |
| Role | kinase |
| Enzymatic Domains |
Ig-like C2-type 1 22-118
Ig-like C2-type 2 152-240
Ig-like C2-type 3 249-349
Protein kinase 467-755 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR4 | FGFR4 | Tyr642 | RGVHHIDyYKKTSNG | phosphorylation up-regulates | 18670643 | SIGNOR-179776 |
| FGFR4 | FGFR4 | Tyr643 | GVHHIDYyKKTSNGR | phosphorylation up-regulates | 18670643 | SIGNOR-179780 |
| FGFR4 | FGFR4 | Tyr754 | LLAVSEEyLDLRLTF | phosphorylation up-regulates activity | 8576110 | SIGNOR-251140 |
| FGFR4 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 10918587 | SIGNOR-251142 |
| FGFR4 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 10918587 | SIGNOR-251141 |
| FGFR4 | GLO1 | Tyr136 | GIAVPDVySACKRFE | phosphorylation up-regulates activity | 34838714 | SIGNOR-276182 |
| FGFR4 | STK4 | – | phosphorylation down-regulates activity | 30903103 | SIGNOR-279714 | |
| FGFR4 | FRS2 | – | phosphorylation up-regulates activity | 9182757 | SIGNOR-242661 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR4 | phosphorylation up-regulates → | FGFR4 PTyr642 | phosphorylation up-regulates → | FGFR4 | 18670643 | SIGNOR-179776 |
| FGFR4 | phosphorylation up-regulates → | FGFR4 PTyr643 | phosphorylation up-regulates → | FGFR4 | 18670643 | SIGNOR-179780 |
| FGFR4 | phosphorylation up-regulates → | FGFR4 PTyr754 | phosphorylation up-regulates → | FGFR4 | 8576110 | SIGNOR-251140 |
| FGFR4 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 10918587 | SIGNOR-251142 |
| FGFR4 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 10918587 | SIGNOR-251141 |
| FGFR4 | phosphorylation up-regulates → | GLO1 PTyr136 | phosphorylation up-regulates → | GLO1 | 34838714 | SIGNOR-276182 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FGFR4 | phosphorylation → up-regulates | FGFR4 | SIGNOR-179776 |
| FGFR4 | phosphorylation → up-regulates | FGFR4 | SIGNOR-179780 |
| FGFR4 | phosphorylation → up-regulates activity | FGFR4 | SIGNOR-251140 |
| FGFR4 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-251142 |
| FGFR4 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-251141 |
| FGFR4 | phosphorylation → up-regulates activity | GLO1 | SIGNOR-276182 |
| FGFR4 | phosphorylation → down-regulates activity | STK4 | SIGNOR-279714 |
| FGFR4 | phosphorylation → up-regulates activity | FRS2 | SIGNOR-242661 |