Entity Details

Name FGFR3
ID P22607
Role substrate
Enzymatic Domains
Ig-like C2-type 1 24-126
Ig-like C2-type 2 151-244
Ig-like C2-type 3 253-355
Protein kinase 472-761
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
FGFR3FGFR3Tyr577RRPPGLDySFDTCKPphosphorylation
up-regulates activity		11294897SIGNOR-106726
FGFR3FGFR3Tyr647RDVHNLDyYKKTTNGphosphorylation
up-regulates activity		11294897SIGNOR-106730
FGFR3FGFR3Tyr760TVTSTDEyLDLSAPFphosphorylation
up-regulates activity		11294897SIGNOR-106742
FGFR3FGFR3Tyr648DVHNLDYyKKTTNGRphosphorylation
up-regulates activity		11294897SIGNOR-106734
FGFR3FGFR3Tyr770LSAPFEQySPGGQDTphosphorylation
down-regulates activity		11294897SIGNOR-106746
FGFR3FGFR3Tyr724ANCTHDLyMIMRECWphosphorylation
up-regulates activity		11294897SIGNOR-106738
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
FGFR3phosphorylation
up-regulates
→
FGFR3
PTyr577		phosphorylation
up-regulates
→		FGFR311294897SIGNOR-106726
FGFR3phosphorylation
up-regulates
→
FGFR3
PTyr647		phosphorylation
up-regulates
→		FGFR311294897SIGNOR-106730
FGFR3phosphorylation
up-regulates
→
FGFR3
PTyr760		phosphorylation
up-regulates
→		FGFR311294897SIGNOR-106742
FGFR3phosphorylation
up-regulates
→
FGFR3
PTyr648		phosphorylation
up-regulates
→		FGFR311294897SIGNOR-106734
FGFR3phosphorylation
up-regulates
→
FGFR3
PTyr770		phosphorylation
down-regulates
⊣		FGFR311294897SIGNOR-106746
FGFR3phosphorylation
up-regulates
→
FGFR3
PTyr724		phosphorylation
up-regulates
→		FGFR311294897SIGNOR-106738
Regulator Mechanism/Effect Target SIGNOR-ID
FGFR3phosphorylation
→
up-regulates activity 		FGFR3SIGNOR-106726
FGFR3phosphorylation
→
up-regulates activity 		FGFR3SIGNOR-106730
FGFR3phosphorylation
→
up-regulates activity 		FGFR3SIGNOR-106742
FGFR3phosphorylation
→
up-regulates activity 		FGFR3SIGNOR-106734
FGFR3phosphorylation
→
down-regulates activity 		FGFR3SIGNOR-106746
FGFR3phosphorylation
→
up-regulates activity 		FGFR3SIGNOR-106738