| Name | PRKACG |
| ID | P22612 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 44-298 PROSITE-ProRule
AGC-kinase C-terminal 299-351 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACG | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-112375 |
| PRKACG | PHKA2 | – | phosphorylation down-regulates activity | 10487978 | SIGNOR-267414 | |
| PRKACG | PHKA1 | – | phosphorylation down-regulates activity | 10487978 | SIGNOR-267415 | |
| PRKACG | MYBPC3 | Ser275 | LSAFRRTsLAGGGRR | phosphorylation up-regulates | 20151718 | SIGNOR-163784 |
| PRKACG | MYBPC3 | Ser284 | AGGGRRIsDSHEDTG | phosphorylation up-regulates | 20151718 | SIGNOR-163788 |
| PRKACG | MYBPC3 | Ser304 | SLLKKRDsFRTPRDS | phosphorylation up-regulates | 20151718 | SIGNOR-163792 |
| PRKACG | MYBPC3 | Ser311 | SFRTPRDsKLEAPAE | phosphorylation up-regulates | 20151718 | SIGNOR-163796 |
| PRKACG | TENT2 | Ser116 | LSGERRYsMPPLFHT | phosphorylation down-regulates activity | 31057087 | SIGNOR-259404 |
| PRKACG | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10230396 | SIGNOR-67392 |
| PRKACG | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 10230396 | SIGNOR-67396 |
| PRKACG | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81153 |
| PRKACG | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 10949026 | SIGNOR-81157 |
| PRKACG | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81161 |
| PRKACG | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 10949026 | SIGNOR-67400 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACG | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-112375 |
| PRKACG | phosphorylation up-regulates → | MYBPC3 PSer275 | phosphorylation up-regulates → | MYBPC3 | 20151718 | SIGNOR-163784 |
| PRKACG | phosphorylation up-regulates → | MYBPC3 PSer284 | phosphorylation up-regulates → | MYBPC3 | 20151718 | SIGNOR-163788 |
| PRKACG | phosphorylation up-regulates → | MYBPC3 PSer304 | phosphorylation up-regulates → | MYBPC3 | 20151718 | SIGNOR-163792 |
| PRKACG | phosphorylation up-regulates → | MYBPC3 PSer311 | phosphorylation up-regulates → | MYBPC3 | 20151718 | SIGNOR-163796 |
| PRKACG | phosphorylation up-regulates → | TENT2 PSer116 | phosphorylation down-regulates ⊣ | TENT2 | 31057087 | SIGNOR-259404 |
| PRKACG | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10230396 | SIGNOR-67392 |
| PRKACG | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10230396 | SIGNOR-67396 |
| PRKACG | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81153 |
| PRKACG | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81157 |
| PRKACG | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81161 |
| PRKACG | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-67400 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACG | phosphorylation → up-regulates | NOS3 | SIGNOR-112375 |
| PRKACG | phosphorylation → down-regulates activity | PHKA2 | SIGNOR-267414 |
| PRKACG | phosphorylation → down-regulates activity | PHKA1 | SIGNOR-267415 |
| PRKACG | phosphorylation → up-regulates | MYBPC3 | SIGNOR-163784 |
| PRKACG | phosphorylation → up-regulates | MYBPC3 | SIGNOR-163788 |
| PRKACG | phosphorylation → up-regulates | MYBPC3 | SIGNOR-163792 |
| PRKACG | phosphorylation → up-regulates | MYBPC3 | SIGNOR-163796 |
| PRKACG | phosphorylation → down-regulates activity | TENT2 | SIGNOR-259404 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-67392 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-67396 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-81153 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-81157 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-81161 |
| PRKACG | phosphorylation → down-regulates activity | BAD | SIGNOR-67400 |