Entity Details

Name PRKACB
ID P22694
Role kinase
Enzymatic Domains
Protein kinase 44-298
PROSITE-ProRule
AGC-kinase C-terminal 299-351
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKACBNGFRSer303PEGEKLHsDSGISVDphosphorylation
up-regulates
12682012SIGNOR-99755
PRKACBPHKA2–phosphorylation
down-regulates activity
10487978SIGNOR-267412
PRKACBPHKA1–phosphorylation
down-regulates activity
10487978SIGNOR-267413
PRKACBMYBPC3Ser275LSAFRRTsLAGGGRRphosphorylation
up-regulates
20151718SIGNOR-163768
PRKACBMYBPC3Ser284AGGGRRIsDSHEDTGphosphorylation
up-regulates
20151718SIGNOR-163772
PRKACBMYBPC3Ser304SLLKKRDsFRTPRDSphosphorylation
up-regulates
20151718SIGNOR-163776
PRKACBMYBPC3Ser311SFRTPRDsKLEAPAEphosphorylation
up-regulates
20151718SIGNOR-163780
PRKACBTENT2Ser116LSGERRYsMPPLFHTphosphorylation
down-regulates activity
31057087SIGNOR-259403
PRKACBGPKOWSer27SFGFTRTsARRRLADphosphorylation
up-regulates activity
21880142SIGNOR-266299
PRKACBGPKOWSer27SFGFTRTsARRRLADphosphorylation
up-regulates activity
21880142SIGNOR-266311
PRKACBGPKOWThr316GTASSRKtLWNQELYphosphorylation
up-regulates activity
21880142SIGNOR-266310
PRKACBGPKOWThr316GTASSRKtLWNQELYphosphorylation
up-regulates activity
21880142SIGNOR-266298
PRKACBBADSer118GRELRRMsDEFVDSFphosphorylation
down-regulates
10949026SIGNOR-81141
PRKACBBADSer75EIRSRHSsYPAGTEDphosphorylation
down-regulates
10949026SIGNOR-81145
PRKACBBADSer99PFRGRSRsAPPNLWAphosphorylation
down-regulates
10949026SIGNOR-81149
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKACBphosphorylation
up-regulates
→
NGFR
PSer303
phosphorylation
up-regulates
→
NGFR12682012SIGNOR-99755
PRKACBphosphorylation
up-regulates
→
MYBPC3
PSer275
phosphorylation
up-regulates
→
MYBPC320151718SIGNOR-163768
PRKACBphosphorylation
up-regulates
→
MYBPC3
PSer284
phosphorylation
up-regulates
→
MYBPC320151718SIGNOR-163772
PRKACBphosphorylation
up-regulates
→
MYBPC3
PSer304
phosphorylation
up-regulates
→
MYBPC320151718SIGNOR-163776
PRKACBphosphorylation
up-regulates
→
MYBPC3
PSer311
phosphorylation
up-regulates
→
MYBPC320151718SIGNOR-163780
PRKACBphosphorylation
up-regulates
→
TENT2
PSer116
phosphorylation
down-regulates
⊣
TENT231057087SIGNOR-259403
PRKACBphosphorylation
up-regulates
→
GPKOW
PSer27
phosphorylation
up-regulates
→
GPKOW21880142SIGNOR-266299
PRKACBphosphorylation
up-regulates
→
GPKOW
PSer27
phosphorylation
up-regulates
→
GPKOW21880142SIGNOR-266311
PRKACBphosphorylation
up-regulates
→
GPKOW
PThr316
phosphorylation
up-regulates
→
GPKOW21880142SIGNOR-266310
PRKACBphosphorylation
up-regulates
→
GPKOW
PThr316
phosphorylation
up-regulates
→
GPKOW21880142SIGNOR-266298
PRKACBphosphorylation
up-regulates
→
BAD
PSer118
phosphorylation
down-regulates
⊣
BAD10949026SIGNOR-81141
PRKACBphosphorylation
up-regulates
→
BAD
PSer75
phosphorylation
down-regulates
⊣
BAD10949026SIGNOR-81145
PRKACBphosphorylation
up-regulates
→
BAD
PSer99
phosphorylation
down-regulates
⊣
BAD10949026SIGNOR-81149
Regulator Mechanism/Effect Target SIGNOR-ID
PRKACBphosphorylation
→
up-regulates
NGFRSIGNOR-99755
PRKACBphosphorylation
→
down-regulates activity
PHKA2SIGNOR-267412
PRKACBphosphorylation
→
down-regulates activity
PHKA1SIGNOR-267413
PRKACBphosphorylation
→
up-regulates
MYBPC3SIGNOR-163768
PRKACBphosphorylation
→
up-regulates
MYBPC3SIGNOR-163772
PRKACBphosphorylation
→
up-regulates
MYBPC3SIGNOR-163776
PRKACBphosphorylation
→
up-regulates
MYBPC3SIGNOR-163780
PRKACBphosphorylation
→
down-regulates activity
TENT2SIGNOR-259403
PRKACBphosphorylation
→
up-regulates activity
GPKOWSIGNOR-266299
PRKACBphosphorylation
→
up-regulates activity
GPKOWSIGNOR-266311
PRKACBphosphorylation
→
up-regulates activity
GPKOWSIGNOR-266310
PRKACBphosphorylation
→
up-regulates activity
GPKOWSIGNOR-266298
PRKACBphosphorylation
img/direct_inhibition.png
down-regulates
BADSIGNOR-81141
PRKACBphosphorylation
img/direct_inhibition.png
down-regulates
BADSIGNOR-81145
PRKACBphosphorylation
img/direct_inhibition.png
down-regulates
BADSIGNOR-81149