| Name | NR4A1 |
| ID | P22736 |
| Role | substrate |
| Enzymatic Domains |
NR LBD 360-595 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | NR4A1 | Ser95 | TSSSSATsPASASFK | phosphorylation down-regulates | 17023523 | SIGNOR-149998 |
| MAPK1 | NR4A1 | Thr143 | CSAPSPStPSFQPPQ | phosphorylation up-regulates activity | 11883936 | SIGNOR-249430 |
| AKT | NR4A1 | Ser351 | GRRGRLPsKPKQPPD | phosphorylation down-regulates activity | 11274386 | SIGNOR-105927 |
| RPS6KA5 | NR4A1 | Ser351 | GRRGRLPsKPKQPPD | phosphorylation unknown | 16223362 | SIGNOR-249296 |
| AKT1 | NR4A1 | Ser351 | GRRGRLPsKPKQPPD | phosphorylation down-regulates activity | 11274386 | SIGNOR-252466 |
| RPS6KA3 | NR4A1 | Ser351 | GRRGRLPsKPKQPPD | phosphorylation unknown | 16223362 | SIGNOR-249295 |
| RPS6KA2 | NR4A1 | Ser351 | GRRGRLPsKPKQPPD | phosphorylation down-regulates activity | 11883936 | SIGNOR-249429 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | NR4A1 PSer95 | phosphorylation down-regulates ⊣ | NR4A1 | 17023523 | SIGNOR-149998 |
| MAPK1 | phosphorylation up-regulates → | NR4A1 PThr143 | phosphorylation up-regulates → | NR4A1 | 11883936 | SIGNOR-249430 |
| AKT | phosphorylation up-regulates → | NR4A1 PSer351 | phosphorylation down-regulates ⊣ | NR4A1 | 11274386 | SIGNOR-105927 |
| RPS6KA5 | phosphorylation up-regulates → | NR4A1 PSer351 | phosphorylation down-regulates ⊣ | NR4A1 | 16223362 | SIGNOR-249296 |
| AKT1 | phosphorylation up-regulates → | NR4A1 PSer351 | phosphorylation down-regulates ⊣ | NR4A1 | 11274386 | SIGNOR-252466 |
| RPS6KA3 | phosphorylation up-regulates → | NR4A1 PSer351 | phosphorylation down-regulates ⊣ | NR4A1 | 16223362 | SIGNOR-249295 |
| RPS6KA2 | phosphorylation up-regulates → | NR4A1 PSer351 | phosphorylation down-regulates ⊣ | NR4A1 | 11883936 | SIGNOR-249429 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation down-regulates | NR4A1 | SIGNOR-149998 |
| MAPK1 | phosphorylation → up-regulates activity | NR4A1 | SIGNOR-249430 |
| AKT | phosphorylation → down-regulates activity | NR4A1 | SIGNOR-105927 |
| RPS6KA5 | phosphorylation → unknown | NR4A1 | SIGNOR-249296 |
| AKT1 | phosphorylation → down-regulates activity | NR4A1 | SIGNOR-252466 |
| RPS6KA3 | phosphorylation → unknown | NR4A1 | SIGNOR-249295 |
| RPS6KA2 | phosphorylation → down-regulates activity | NR4A1 | SIGNOR-249429 |