| Name | PTPRD |
| ID | P23468 |
| Role | phosphatase |
| Enzymatic Domains |
Ig-like C2-type 1 24-114
Ig-like C2-type 2 126-224
Ig-like C2-type 3 236-318
Fibronectin type-III 1 325-415 PROSITE-ProRule
Fibronectin type-III 2 420-516 PROSITE-ProRule
Fibronectin type-III 3 518-607 PROSITE-ProRule
Fibronectin type-III 4 612-709 PROSITE-ProRule
Fibronectin type-III 5 714-822 PROSITE-ProRule
Fibronectin type-III 6 823-916 PROSITE-ProRule
Fibronectin type-III 7 921-1016 PROSITE-ProRule
Fibronectin type-III 8 1020-1106 PROSITE-ProRule
Tyrosine-protein phosphatase 1 1357-1612 PROSITE-ProRule
Tyrosine-protein phosphatase 2 1644-1903 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRD | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates | 19478061 | SIGNOR-185933 |
| PTPRD | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 19478061 | SIGNOR-248442 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRD | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 19478061 | SIGNOR-185933 |
| PTPRD | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 19478061 | SIGNOR-248442 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRD | dephosphorylation down-regulates | STAT3 | SIGNOR-185933 |
| PTPRD | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248442 |