| Name | PTPRG |
| ID | P23470 |
| Role | phosphatase |
| Enzymatic Domains |
Alpha-carbonic anhydrase 58-321 PROSITE-ProRule
Fibronectin type-III 349-448 PROSITE-ProRule
Tyrosine-protein phosphatase 1 848-1119 PROSITE-ProRule
Tyrosine-protein phosphatase 2 1150-1410 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | DOK2 | Tyr139 | CMEENELySSAVTVG | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254698 |
| PTPRG | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254689 |
| PTPRG | JAK2 | Tyr1008 | LPQDKEYyKVKEPGE | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254690 |
| PTPRG | DAB1 | Tyr198 | EDVEDPVyQYIVFEA | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254697 |
| PTPRG | ABL1 | Tyr413 | TAPESLAyNKFSIKS | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254691 |
| PTPRG | EGFR | Tyr1069 | EDSFLQRySSDPTGA | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254699 |
| PTPRG | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254700 |
| PTPRG | ERBB2 | Tyr1248 | PTAENPEyLGLDVPV | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254701 |
| PTPRG | ITGB1 | Tyr783 | DTGENPIyKSAVTTV | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254706 |
| PTPRG | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254704 |
| PTPRG | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254705 |
| PTPRG | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254703 |
| PTPRG | MET | Tyr1003 | VSNESVDyRATFPED | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254712 |
| PTPRG | PDGFRB | Tyr716 | RPPSAELySNALPVG | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254715 |
| PTPRG | KIT | Tyr703 | DHAEAALyKNLLHSK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254709 |
| PTPRG | KIT | Tyr730 | DMKPGVSyVVPTKAD | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254710 |
| PTPRG | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254725 |
| PTPRG | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254726 |
| PTPRG | PDGFRA | Tyr742 | KQADTTQyVPMLERK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254713 |
| PTPRG | PDGFRA | Tyr754 | ERKEVSKySDIQRSL | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254714 |
| PTPRG | VCL | Tyr822 | KSFLDSGyRILGAVA | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254731 |
| PTPRG | CDK2 | Tyr15 | EKIGEGTyGVVYKAR | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254695 |
| PTPRG | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254723 |
| PTPRG | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254724 |
| PTPRG | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254707 |
| PTPRG | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254708 |
| PTPRG | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254729 |
| PTPRG | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254727 |
| PTPRG | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254730 |
| PTPRG | ZAP70 | Tyr292 | DTLNSDGyTPEPARI | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254732 |
| PTPRG | ZAP70 | Tyr315 | MPMDTSVyESPYSDP | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254733 |
| PTPRG | ZAP70 | Tyr319 | TSVYESPySDPEELK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254734 |
| PTPRG | PXN | Tyr118 | VGEEEHVySFPNKQK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254721 |
| PTPRG | PXN | – | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254722 | |
| PTPRG | BMX | Tyr40 | LTKTNLSyYEYDKMK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254693 |
| PTPRG | STAT2 | Tyr690 | NLQERRKyLKHRLIV | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254728 |
| PTPRG | LIMK1 | Tyr507 | KPDRKKRyTVVGNPY | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254711 |
| PTPRG | PTK2 | Tyr577 | YMEDSTYyKASKGKL | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254718 |
| PTPRG | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254720 |
| PTPRG | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254717 |
| PTPRG | PTK2 | Tyr576 | RYMEDSTyYKASKGK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254719 |
| PTPRG | PRKCD | Tyr313 | SSEPVGIyQGFEKKT | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254716 |
| PTPRG | BTK | Tyr223 | LKKVVALyDYMPMNA | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254694 |
| PTPRG | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254702 |
| PTPRG | CTTN | Tyr470 | AYATEAVyESAEAPG | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254696 |
| PTPRG | BLNK | Tyr84 | EHSDSEMyVMPAEEN | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254692 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | dephosphorylation down-regulates ⊣ | DOK2 PTyr139 | dephosphorylation down-regulates ⊣ | DOK2 | 25624455 | SIGNOR-254698 |
| PTPRG | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 25624455 | SIGNOR-254689 |
| PTPRG | dephosphorylation down-regulates ⊣ | JAK2 PTyr1008 | dephosphorylation up-regulates → | JAK2 | 25624455 | SIGNOR-254690 |
| PTPRG | dephosphorylation down-regulates ⊣ | DAB1 PTyr198 | dephosphorylation up-regulates → | DAB1 | 25624455 | SIGNOR-254697 |
| PTPRG | dephosphorylation down-regulates ⊣ | ABL1 PTyr413 | dephosphorylation up-regulates → | ABL1 | 25624455 | SIGNOR-254691 |
| PTPRG | dephosphorylation down-regulates ⊣ | EGFR PTyr1069 | dephosphorylation up-regulates → | EGFR | 25624455 | SIGNOR-254699 |
| PTPRG | dephosphorylation down-regulates ⊣ | EGFR PTyr1172 | dephosphorylation down-regulates ⊣ | EGFR | 25624455 | SIGNOR-254700 |
| PTPRG | dephosphorylation down-regulates ⊣ | ERBB2 PTyr1248 | dephosphorylation down-regulates ⊣ | ERBB2 | 25624455 | SIGNOR-254701 |
| PTPRG | dephosphorylation down-regulates ⊣ | ITGB1 PTyr783 | dephosphorylation up-regulates → | ITGB1 | 25624455 | SIGNOR-254706 |
| PTPRG | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation down-regulates ⊣ | INSR | 25624455 | SIGNOR-254704 |
| PTPRG | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation down-regulates ⊣ | INSR | 25624455 | SIGNOR-254705 |
| PTPRG | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation down-regulates ⊣ | INSR | 25624455 | SIGNOR-254703 |
| PTPRG | dephosphorylation down-regulates ⊣ | MET PTyr1003 | dephosphorylation up-regulates → | MET | 25624455 | SIGNOR-254712 |
| PTPRG | dephosphorylation down-regulates ⊣ | PDGFRB PTyr716 | dephosphorylation up-regulates → | PDGFRB | 25624455 | SIGNOR-254715 |
| PTPRG | dephosphorylation down-regulates ⊣ | KIT PTyr703 | dephosphorylation up-regulates → | KIT | 25624455 | SIGNOR-254709 |
| PTPRG | dephosphorylation down-regulates ⊣ | KIT PTyr730 | dephosphorylation up-regulates → | KIT | 25624455 | SIGNOR-254710 |
| PTPRG | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 25624455 | SIGNOR-254725 |
| PTPRG | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation up-regulates → | SRC | 25624455 | SIGNOR-254726 |
| PTPRG | dephosphorylation down-regulates ⊣ | PDGFRA PTyr742 | dephosphorylation down-regulates ⊣ | PDGFRA | 25624455 | SIGNOR-254713 |
| PTPRG | dephosphorylation down-regulates ⊣ | PDGFRA PTyr754 | dephosphorylation down-regulates ⊣ | PDGFRA | 25624455 | SIGNOR-254714 |
| PTPRG | dephosphorylation down-regulates ⊣ | VCL PTyr822 | dephosphorylation up-regulates → | VCL | 25624455 | SIGNOR-254731 |
| PTPRG | dephosphorylation down-regulates ⊣ | CDK2 PTyr15 | dephosphorylation up-regulates → | CDK2 | 25624455 | SIGNOR-254695 |
| PTPRG | dephosphorylation down-regulates ⊣ | SHC1 PTyr349 | dephosphorylation up-regulates → | SHC1 | 25624455 | SIGNOR-254723 |
| PTPRG | dephosphorylation down-regulates ⊣ | SHC1 PTyr350 | dephosphorylation up-regulates → | SHC1 | 25624455 | SIGNOR-254724 |
| PTPRG | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 25624455 | SIGNOR-254707 |
| PTPRG | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 25624455 | SIGNOR-254708 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation down-regulates ⊣ | STAT3 | 25624455 | SIGNOR-254729 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation down-regulates ⊣ | STAT1 | 25624455 | SIGNOR-254727 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT5A PTyr694 | dephosphorylation down-regulates ⊣ | STAT5A | 25624455 | SIGNOR-254730 |
| PTPRG | dephosphorylation down-regulates ⊣ | ZAP70 PTyr292 | dephosphorylation down-regulates ⊣ | ZAP70 | 25624455 | SIGNOR-254732 |
| PTPRG | dephosphorylation down-regulates ⊣ | ZAP70 PTyr315 | dephosphorylation down-regulates ⊣ | ZAP70 | 25624455 | SIGNOR-254733 |
| PTPRG | dephosphorylation down-regulates ⊣ | ZAP70 PTyr319 | dephosphorylation down-regulates ⊣ | ZAP70 | 25624455 | SIGNOR-254734 |
| PTPRG | dephosphorylation down-regulates ⊣ | PXN PTyr118 | dephosphorylation down-regulates ⊣ | PXN | 25624455 | SIGNOR-254721 |
| PTPRG | dephosphorylation down-regulates ⊣ | BMX PTyr40 | dephosphorylation up-regulates → | BMX | 25624455 | SIGNOR-254693 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT2 PTyr690 | dephosphorylation down-regulates ⊣ | STAT2 | 25624455 | SIGNOR-254728 |
| PTPRG | dephosphorylation down-regulates ⊣ | LIMK1 PTyr507 | dephosphorylation up-regulates → | LIMK1 | 25624455 | SIGNOR-254711 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr577 | dephosphorylation up-regulates → | PTK2 | 25624455 | SIGNOR-254718 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr861 | dephosphorylation up-regulates → | PTK2 | 25624455 | SIGNOR-254720 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation down-regulates ⊣ | PTK2 | 25624455 | SIGNOR-254717 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr576 | dephosphorylation down-regulates ⊣ | PTK2 | 25624455 | SIGNOR-254719 |
| PTPRG | dephosphorylation down-regulates ⊣ | PRKCD PTyr313 | dephosphorylation down-regulates ⊣ | PRKCD | 25624455 | SIGNOR-254716 |
| PTPRG | dephosphorylation down-regulates ⊣ | BTK PTyr223 | dephosphorylation up-regulates → | BTK | 25624455 | SIGNOR-254694 |
| PTPRG | dephosphorylation down-regulates ⊣ | GRIN2B PTyr1474 | dephosphorylation down-regulates ⊣ | GRIN2B | 25624455 | SIGNOR-254702 |
| PTPRG | dephosphorylation down-regulates ⊣ | CTTN PTyr470 | dephosphorylation up-regulates → | CTTN | 25624455 | SIGNOR-254696 |
| PTPRG | dephosphorylation down-regulates ⊣ | BLNK PTyr84 | dephosphorylation down-regulates ⊣ | BLNK | 25624455 | SIGNOR-254692 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRG | dephosphorylation → up-regulates activity | DOK2 | SIGNOR-254698 |
| PTPRG | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-254689 |
| PTPRG | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-254690 |
| PTPRG | dephosphorylation → down-regulates activity | DAB1 | SIGNOR-254697 |
| PTPRG | dephosphorylation → down-regulates activity | ABL1 | SIGNOR-254691 |
| PTPRG | dephosphorylation → down-regulates activity | EGFR | SIGNOR-254699 |
| PTPRG | dephosphorylation → up-regulates activity | EGFR | SIGNOR-254700 |
| PTPRG | dephosphorylation → up-regulates activity | ERBB2 | SIGNOR-254701 |
| PTPRG | dephosphorylation → down-regulates activity | ITGB1 | SIGNOR-254706 |
| PTPRG | dephosphorylation → up-regulates activity | INSR | SIGNOR-254704 |
| PTPRG | dephosphorylation → up-regulates activity | INSR | SIGNOR-254705 |
| PTPRG | dephosphorylation → up-regulates activity | INSR | SIGNOR-254703 |
| PTPRG | dephosphorylation → down-regulates activity | MET | SIGNOR-254712 |
| PTPRG | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-254715 |
| PTPRG | dephosphorylation → down-regulates activity | KIT | SIGNOR-254709 |
| PTPRG | dephosphorylation → down-regulates activity | KIT | SIGNOR-254710 |
| PTPRG | dephosphorylation → down-regulates activity | SRC | SIGNOR-254725 |
| PTPRG | dephosphorylation → down-regulates activity | SRC | SIGNOR-254726 |
| PTPRG | dephosphorylation → up-regulates activity | PDGFRA | SIGNOR-254713 |
| PTPRG | dephosphorylation → up-regulates activity | PDGFRA | SIGNOR-254714 |
| PTPRG | dephosphorylation → down-regulates activity | VCL | SIGNOR-254731 |
| PTPRG | dephosphorylation → down-regulates activity | CDK2 | SIGNOR-254695 |
| PTPRG | dephosphorylation → down-regulates activity | SHC1 | SIGNOR-254723 |
| PTPRG | dephosphorylation → down-regulates activity | SHC1 | SIGNOR-254724 |
| PTPRG | dephosphorylation → down-regulates activity | KDR | SIGNOR-254707 |
| PTPRG | dephosphorylation → down-regulates activity | KDR | SIGNOR-254708 |
| PTPRG | dephosphorylation → up-regulates activity | STAT3 | SIGNOR-254729 |
| PTPRG | dephosphorylation → up-regulates activity | STAT1 | SIGNOR-254727 |
| PTPRG | dephosphorylation → up-regulates activity | STAT5A | SIGNOR-254730 |
| PTPRG | dephosphorylation → up-regulates activity | ZAP70 | SIGNOR-254732 |
| PTPRG | dephosphorylation → up-regulates activity | ZAP70 | SIGNOR-254733 |
| PTPRG | dephosphorylation → up-regulates activity | ZAP70 | SIGNOR-254734 |
| PTPRG | dephosphorylation → up-regulates activity | PXN | SIGNOR-254721 |
| PTPRG | dephosphorylation → up-regulates activity | PXN | SIGNOR-254722 |
| PTPRG | dephosphorylation → down-regulates activity | BMX | SIGNOR-254693 |
| PTPRG | dephosphorylation → up-regulates activity | STAT2 | SIGNOR-254728 |
| PTPRG | dephosphorylation → down-regulates activity | LIMK1 | SIGNOR-254711 |
| PTPRG | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-254718 |
| PTPRG | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-254720 |
| PTPRG | dephosphorylation → up-regulates activity | PTK2 | SIGNOR-254717 |
| PTPRG | dephosphorylation → up-regulates activity | PTK2 | SIGNOR-254719 |
| PTPRG | dephosphorylation → up-regulates activity | PRKCD | SIGNOR-254716 |
| PTPRG | dephosphorylation → down-regulates activity | BTK | SIGNOR-254694 |
| PTPRG | dephosphorylation → up-regulates activity | GRIN2B | SIGNOR-254702 |
| PTPRG | dephosphorylation → down-regulates activity | CTTN | SIGNOR-254696 |
| PTPRG | dephosphorylation → up-regulates activity | BLNK | SIGNOR-254692 |