Entity Details

Name PTPRZ1
ID P23471
Role phosphatase
Enzymatic Domains
Alpha-carbonic anhydrase 36-300
PROSITE-ProRule
Fibronectin type-III 314-413
PROSITE-ProRule
Tyrosine-protein phosphatase 1 1717-1992
PROSITE-ProRule
Tyrosine-protein phosphatase 2 2023-2282
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPRZ1CTNNB1–dephosphorylation
up-regulates activity		23100427SIGNOR-277044
PTPRZ1ARHGAP35Tyr1105RNEEENIySVPHDSTdephosphorylation
down-regulates activity		16513268SIGNOR-248451
PTPRZ1ALK–dephosphorylation
down-regulates		17681947SIGNOR-157227
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPRZ1dephosphorylation
down-regulates
⊣
ARHGAP35
PTyr1105		dephosphorylation
up-regulates
→		ARHGAP3516513268SIGNOR-248451
Regulator Mechanism/Effect Target SIGNOR-ID
PTPRZ1dephosphorylation
→
up-regulates activity 		CTNNB1SIGNOR-277044
PTPRZ1dephosphorylation
→
down-regulates activity 		ARHGAP35SIGNOR-248451
PTPRZ1dephosphorylation
img/direct_inhibition.png
down-regulates 		ALKSIGNOR-157227