| Name | CFL1 |
| ID | P23528 |
| Role | substrate |
| Enzymatic Domains |
ADF-H 4-153 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | CFL1 | Ser24 | DMKVRKSsTPEEVKK | phosphorylation down-regulates | 22855535 | SIGNOR-198482 |
| SRC | CFL1 | Tyr68 | GQTVDDPyATFVKML | phosphorylation down-regulates | 19802004 | SIGNOR-188352 |
| TESK1 | CFL1 | Ser3 | sGVAVSDG | phosphorylation down-regulates activity | 11418599 | SIGNOR-246723 |
| LIMK1 | CFL1 | Ser3 | sGVAVSDG | phosphorylation down-regulates | 18079118 | SIGNOR-159885 |
| AURKA | CFL1 | – | phosphorylation down-regulates activity | 27003257 | SIGNOR-279798 | |
| SSH2 | CFL1 | Ser3 | sGVAVSDG | dephosphorylation up-regulates activity | 14531860 | SIGNOR-248733 |
| SSH3 | CFL1 | Ser3 | sGVAVSDG | dephosphorylation up-regulates activity | 14531860 | SIGNOR-248759 |
| TESK1 | CFL1 | Ser3 | sGVAVSDG | phosphorylation down-regulates activity | 11294912 | SIGNOR-106777 |
| ILK | CFL1 | Ser3 | sGVAVSDG | phosphorylation down-regulates | 18252715 | SIGNOR-160756 |
| LIMK2 | CFL1 | Ser3 | sGVAVSDG | phosphorylation down-regulates activity | 11171090 | SIGNOR-105098 |
| PRKCA | CFL1 | Ser23 | NDMKVRKsSTPEEVK | phosphorylation down-regulates | 22855535 | SIGNOR-198478 |
| PTEN | CFL1 | – | dephosphorylation up-regulates activity | 22317922 | SIGNOR-276980 | |
| PRKD1 | CFL1 | Ser3 | sGVAVSDG | phosphorylation down-regulates activity | 19329994 | SIGNOR-275944 |
| SSH1 | CFL1 | Ser3 | sGVAVSDG | dephosphorylation up-regulates activity | 14531860 | SIGNOR-248762 |
| TESK2 | CFL1 | Ser3 | sGVAVSDG | phosphorylation down-regulates activity | 11418599 | SIGNOR-108753 |
| PDXP | CFL1 | Ser3 | sGVAVSDG | dephosphorylation down-regulates activity | 15580268 | SIGNOR-248764 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | CFL1 PSer24 | phosphorylation down-regulates ⊣ | CFL1 | 22855535 | SIGNOR-198482 |
| SRC | phosphorylation up-regulates → | CFL1 PTyr68 | phosphorylation down-regulates ⊣ | CFL1 | 19802004 | SIGNOR-188352 |
| TESK1 | phosphorylation up-regulates → | CFL1 PSer3 | phosphorylation down-regulates ⊣ | CFL1 | 11418599 | SIGNOR-246723 |
| LIMK1 | phosphorylation up-regulates → | CFL1 PSer3 | phosphorylation down-regulates ⊣ | CFL1 | 18079118 | SIGNOR-159885 |
| SSH2 | dephosphorylation down-regulates ⊣ | CFL1 PSer3 | dephosphorylation down-regulates ⊣ | CFL1 | 14531860 | SIGNOR-248733 |
| SSH3 | dephosphorylation down-regulates ⊣ | CFL1 PSer3 | dephosphorylation down-regulates ⊣ | CFL1 | 14531860 | SIGNOR-248759 |
| TESK1 | phosphorylation up-regulates → | CFL1 PSer3 | phosphorylation down-regulates ⊣ | CFL1 | 11294912 | SIGNOR-106777 |
| ILK | phosphorylation up-regulates → | CFL1 PSer3 | phosphorylation down-regulates ⊣ | CFL1 | 18252715 | SIGNOR-160756 |
| LIMK2 | phosphorylation up-regulates → | CFL1 PSer3 | phosphorylation down-regulates ⊣ | CFL1 | 11171090 | SIGNOR-105098 |
| PRKCA | phosphorylation up-regulates → | CFL1 PSer23 | phosphorylation down-regulates ⊣ | CFL1 | 22855535 | SIGNOR-198478 |
| PRKD1 | phosphorylation up-regulates → | CFL1 PSer3 | phosphorylation down-regulates ⊣ | CFL1 | 19329994 | SIGNOR-275944 |
| SSH1 | dephosphorylation down-regulates ⊣ | CFL1 PSer3 | dephosphorylation down-regulates ⊣ | CFL1 | 14531860 | SIGNOR-248762 |
| TESK2 | phosphorylation up-regulates → | CFL1 PSer3 | phosphorylation down-regulates ⊣ | CFL1 | 11418599 | SIGNOR-108753 |
| PDXP | dephosphorylation down-regulates ⊣ | CFL1 PSer3 | dephosphorylation up-regulates → | CFL1 | 15580268 | SIGNOR-248764 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation down-regulates | CFL1 | SIGNOR-198482 |
| SRC | phosphorylation down-regulates | CFL1 | SIGNOR-188352 |
| TESK1 | phosphorylation → down-regulates activity | CFL1 | SIGNOR-246723 |
| LIMK1 | phosphorylation down-regulates | CFL1 | SIGNOR-159885 |
| AURKA | phosphorylation → down-regulates activity | CFL1 | SIGNOR-279798 |
| SSH2 | dephosphorylation → up-regulates activity | CFL1 | SIGNOR-248733 |
| SSH3 | dephosphorylation → up-regulates activity | CFL1 | SIGNOR-248759 |
| TESK1 | phosphorylation → down-regulates activity | CFL1 | SIGNOR-106777 |
| ILK | phosphorylation down-regulates | CFL1 | SIGNOR-160756 |
| LIMK2 | phosphorylation → down-regulates activity | CFL1 | SIGNOR-105098 |
| PRKCA | phosphorylation down-regulates | CFL1 | SIGNOR-198478 |
| PTEN | dephosphorylation → up-regulates activity | CFL1 | SIGNOR-276980 |
| PRKD1 | phosphorylation → down-regulates activity | CFL1 | SIGNOR-275944 |
| SSH1 | dephosphorylation → up-regulates activity | CFL1 | SIGNOR-248762 |
| TESK2 | phosphorylation → down-regulates activity | CFL1 | SIGNOR-108753 |
| PDXP | dephosphorylation → down-regulates activity | CFL1 | SIGNOR-248764 |