| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinK/CDK13 | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates activity | 36882522 | SIGNOR-273116 |
| CDK13 | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates activity | 36882522 | SIGNOR-273115 |
| RPS6KB1 | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates | 15071500 | SIGNOR-123997 |
| RPS6K | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates | 15071500 | SIGNOR-252783 |
| AKT | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates | 18836482 | SIGNOR-181536 |
| AKT1 | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates | 18836482 | SIGNOR-252520 |
| RPS6KA1 | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates | 15071500 | SIGNOR-123993 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinK/CDK13 | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 36882522 | SIGNOR-273116 |
| CDK13 | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 36882522 | SIGNOR-273115 |
| RPS6KB1 | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 15071500 | SIGNOR-123997 |
| RPS6K | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 15071500 | SIGNOR-252783 |
| AKT | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 18836482 | SIGNOR-181536 |
| AKT1 | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 18836482 | SIGNOR-252520 |
| RPS6KA1 | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 15071500 | SIGNOR-123993 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinK/CDK13 | phosphorylation → up-regulates activity | EIF4B | SIGNOR-273116 |
| CDK13 | phosphorylation → up-regulates activity | EIF4B | SIGNOR-273115 |
| RPS6KB1 | phosphorylation → up-regulates | EIF4B | SIGNOR-123997 |
| RPS6K | phosphorylation → up-regulates | EIF4B | SIGNOR-252783 |
| AKT | phosphorylation → up-regulates | EIF4B | SIGNOR-181536 |
| AKT1 | phosphorylation → up-regulates | EIF4B | SIGNOR-252520 |
| RPS6KA1 | phosphorylation → up-regulates | EIF4B | SIGNOR-123993 |
