| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | GATA2 | Thr176 | HLFGFPPtPPKEVSP | phosphorylation down-regulates quantity by destabilization | 25670854 | SIGNOR-276884 |
| AKT | GATA2 | Ser401 | QTRNRKMsNKSKKSK | phosphorylation down-regulates activity | 15837948 | SIGNOR-244271 |
| MAPK14 | GATA2 | – | phosphorylation up-regulates activity | 25056917 | SIGNOR-259946 | |
| HRAS | GATA2 | Ser192 | PSTTGAAsPASSSAG | phosphorylation up-regulates activity | 25056917 | SIGNOR-259945 |
| AKT1 | GATA2 | Ser401 | QTRNRKMsNKSKKSK | phosphorylation down-regulates | 15837948 | SIGNOR-135614 |
| MAPK14 | GATA2 | – | phosphorylation up-regulates | 25056917 | SIGNOR-205242 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | GATA2 PThr176 | phosphorylation down-regulates ⊣ | GATA2 | 25670854 | SIGNOR-276884 |
| AKT | phosphorylation up-regulates → | GATA2 PSer401 | phosphorylation down-regulates ⊣ | GATA2 | 15837948 | SIGNOR-244271 |
| HRAS | phosphorylation up-regulates → | GATA2 PSer192 | phosphorylation up-regulates → | GATA2 | 25056917 | SIGNOR-259945 |
| AKT1 | phosphorylation up-regulates → | GATA2 PSer401 | phosphorylation down-regulates ⊣ | GATA2 | 15837948 | SIGNOR-135614 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation down-regulates quantity by destabilization | GATA2 | SIGNOR-276884 |
| AKT | phosphorylation → down-regulates activity | GATA2 | SIGNOR-244271 |
| MAPK14 | phosphorylation → up-regulates activity | GATA2 | SIGNOR-259946 |
| HRAS | phosphorylation → up-regulates activity | GATA2 | SIGNOR-259945 |
| AKT1 | phosphorylation down-regulates | GATA2 | SIGNOR-135614 |
| MAPK14 | phosphorylation → up-regulates | GATA2 | SIGNOR-205242 |
