| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FBXW7 | GATA2 | Thr176 | HLFGFPPtPPKEVSP | ubiquitination down-regulates quantity by destabilization | 25670854 | SIGNOR-256005 |
| CDK1 | GATA2 | Thr176 | HLFGFPPtPPKEVSP | phosphorylation down-regulates quantity by destabilization | 25670854 | SIGNOR-276884 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FBXW7 | ubiquitination ⊣ | GATA2 PThr176 | ubiquitination ⊣ | GATA2 | 25670854 | SIGNOR-256005 |
| CDK1 | phosphorylation up-regulates → | GATA2 PThr176 | phosphorylation down-regulates ⊣ | GATA2 | 25670854 | SIGNOR-276884 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FBXW7 | ubiquitination![]() down-regulates quantity by destabilization | GATA2 | SIGNOR-256005 |
| CDK1 | phosphorylation![]() down-regulates quantity by destabilization | GATA2 | SIGNOR-276884 |