| Name | RRM1 |
| ID | P23921 |
| Role | substrate |
| Enzymatic Domains |
ATP-cone 1-92 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | RRM1 | Ser559 | PYETYEGsPVSKGIL | phosphorylation up-regulates activity | 32712628 | SIGNOR-277522 |
| mTORC2 | RRM1 | Ser631 | IYTRRVLsGEFQIVN | phosphorylation up-regulates activity | 34126361 | SIGNOR-277566 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation up-regulates → | RRM1 PSer559 | phosphorylation up-regulates → | RRM1 | 32712628 | SIGNOR-277522 |
| mTORC2 | phosphorylation up-regulates → | RRM1 PSer631 | phosphorylation up-regulates → | RRM1 | 34126361 | SIGNOR-277566 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | RRM1 | SIGNOR-277522 |
| mTORC2 | phosphorylation → up-regulates activity | RRM1 | SIGNOR-277566 |