| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | FCAR | Ser284 | LTFARTPsVCK | phosphorylation down-regulates activity | 30766540 | SIGNOR-264857 |
| GSK3A | FCAR | Ser284 | LTFARTPsVCK | phosphorylation down-regulates activity | 30766540 | SIGNOR-264856 |
| PPP2CA | FCAR | Ser284 | LTFARTPsVCK | dephosphorylation up-regulates activity | 30766540 | SIGNOR-264858 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | FCAR PSer284 | phosphorylation down-regulates ⊣ | FCAR | 30766540 | SIGNOR-264857 |
| GSK3A | phosphorylation up-regulates → | FCAR PSer284 | phosphorylation down-regulates ⊣ | FCAR | 30766540 | SIGNOR-264856 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FCAR PSer284 | dephosphorylation down-regulates ⊣ | FCAR | 30766540 | SIGNOR-264858 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → down-regulates activity | FCAR | SIGNOR-264857 |
| GSK3A | phosphorylation → down-regulates activity | FCAR | SIGNOR-264856 |
| PPP2CA | dephosphorylation → up-regulates activity | FCAR | SIGNOR-264858 |