| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ACP1 | PDGFRB | Tyr857 | DIMRDSNyISKGSTF | dephosphorylation down-regulates activity | 12149261 | SIGNOR-248452 |
| ACP1 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 19088431 | SIGNOR-248454 |
| ACP1 | PKM | – | dephosphorylation up-regulates activity | 30251652 | SIGNOR-277134 | |
| ACP1 | EPHA2 | Tyr575 | RQSPEDVyFSKSEQL | dephosphorylation down-regulates activity | 21538645 | SIGNOR-246031 |
| ACP1 | EPHA2 | Tyr588 | QLKPLKTyVDPHTYE | dephosphorylation down-regulates activity | 21538645 | SIGNOR-246035 |
| ACP1 | EPHA2 | Tyr594 | TYVDPHTyEDPNQAV | dephosphorylation down-regulates activity | 21538645 | SIGNOR-246039 |
| ACP1 | EPHA2 | Tyr772 | EDDPEATyTTSGGKI | dephosphorylation down-regulates activity | 21538645 | SIGNOR-246027 |
| ACP1 | EPHA2 | Tyr960 | GHQKRIAySLLGLKD | dephosphorylation down-regulates activity | 21538645 | SIGNOR-246023 |
| ACP1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248455 |
| ACP1 | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248456 |
| ACP1 | PTK2 | – | dephosphorylation down-regulates activity | 12815062 | SIGNOR-277064 | |
| ACP1 | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248457 |
| ACP1 | AKT | – | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248458 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ACP1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr857 | dephosphorylation up-regulates → | PDGFRB | 12149261 | SIGNOR-248452 |
| ACP1 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 19088431 | SIGNOR-248454 |
| ACP1 | dephosphorylation down-regulates ⊣ | EPHA2 PTyr575 | dephosphorylation up-regulates → | EPHA2 | 21538645 | SIGNOR-246031 |
| ACP1 | dephosphorylation down-regulates ⊣ | EPHA2 PTyr588 | dephosphorylation up-regulates → | EPHA2 | 21538645 | SIGNOR-246035 |
| ACP1 | dephosphorylation down-regulates ⊣ | EPHA2 PTyr594 | dephosphorylation up-regulates → | EPHA2 | 21538645 | SIGNOR-246039 |
| ACP1 | dephosphorylation down-regulates ⊣ | EPHA2 PTyr772 | dephosphorylation up-regulates → | EPHA2 | 21538645 | SIGNOR-246027 |
| ACP1 | dephosphorylation down-regulates ⊣ | EPHA2 PTyr960 | dephosphorylation up-regulates → | EPHA2 | 21538645 | SIGNOR-246023 |
| ACP1 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 17353188 | SIGNOR-248455 |
| ACP1 | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 17353188 | SIGNOR-248456 |
| ACP1 | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 17353188 | SIGNOR-248457 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ACP1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248452 |
| ACP1 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248454 |
| ACP1 | dephosphorylation → up-regulates activity | PKM | SIGNOR-277134 |
| ACP1 | dephosphorylation → down-regulates activity | EPHA2 | SIGNOR-246031 |
| ACP1 | dephosphorylation → down-regulates activity | EPHA2 | SIGNOR-246035 |
| ACP1 | dephosphorylation → down-regulates activity | EPHA2 | SIGNOR-246039 |
| ACP1 | dephosphorylation → down-regulates activity | EPHA2 | SIGNOR-246027 |
| ACP1 | dephosphorylation → down-regulates activity | EPHA2 | SIGNOR-246023 |
| ACP1 | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248455 |
| ACP1 | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248456 |
| ACP1 | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-277064 |
| ACP1 | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248457 |
| ACP1 | dephosphorylation → down-regulates activity | AKT | SIGNOR-248458 |
