| Name | PRKCH |
| ID | P24723 |
| Role | kinase |
| Enzymatic Domains |
C2 1-118 PROSITE-ProRule
Protein kinase 355-614 PROSITE-ProRule
AGC-kinase C-terminal 615-683 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCH | ANXA1 | Ser27 | EYVQTVKsSKGGPGS | phosphorylation up-regulates | 24103589 | SIGNOR-202792 |
| PRKCH | ITGB2 | Ser745 | FEKEKLKsQWNNDNP | phosphorylation unknown | 11700305 | SIGNOR-249118 |
| PRKCH | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation unknown | 11700305 | SIGNOR-249123 |
| PRKCH | GSTP1 | Ser185 | SAYVGRLsARPKLKA | phosphorylation up-regulates activity | 15604283 | SIGNOR-276015 |
| PRKCH | GSTP1 | Ser43 | VETWQEGsLKASCLY | phosphorylation up-regulates activity | 15604283 | SIGNOR-276014 |
| PRKCH | MAPK1 | – | phosphorylation up-regulates activity | 28939105 | SIGNOR-261910 | |
| PRKCH | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251634 |
| PRKCH | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276049 |
| PRKCH | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11884598 | SIGNOR-115730 |
| PRKCH | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 19836308 | SIGNOR-188585 |
| PRKCH | PTPN11 | Ser576 | CAEMREDsARVYENV | phosphorylation unknown | 11781100 | SIGNOR-249137 |
| PRKCH | PTPN11 | Ser595 | GLMQQQKsFR | phosphorylation unknown | 11781100 | SIGNOR-249140 |
| PRKCH | PRKD1 | Ser738 | ARIIGEKsFRRSVVG | phosphorylation up-regulates | 10197446 | SIGNOR-66730 |
| PRKCH | PRKD1 | Ser742 | GEKSFRRsVVGTPAY | phosphorylation up-regulates | 10197446 | SIGNOR-66734 |
| PRKCH | PRKD2 | Ser706 | ARIIGEKsFRRSVVG | phosphorylation up-regulates | 12058027 | SIGNOR-89423 |
| PRKCH | PRKD2 | Ser710 | GEKSFRRsVVGTPAY | phosphorylation up-regulates | 12058027 | SIGNOR-89427 |
| PRKCH | PRKD2 | Ser876 | QGLAERIsVL | phosphorylation up-regulates | 12058027 | SIGNOR-89431 |
| PRKCH | PRKD2 | Ser706 | ARIIGEKsFRRSVVG | phosphorylation up-regulates activity | 12058027 | SIGNOR-275958 |
| PRKCH | PRKD2 | Ser710 | GEKSFRRsVVGTPAY | phosphorylation up-regulates activity | 12058027 | SIGNOR-275957 |
| PRKCH | PRKD2 | Ser876 | QGLAERIsVL | phosphorylation up-regulates activity | 12058027 | SIGNOR-275956 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCH | phosphorylation up-regulates → | ANXA1 PSer27 | phosphorylation up-regulates → | ANXA1 | 24103589 | SIGNOR-202792 |
| PRKCH | phosphorylation up-regulates → | ITGB2 PSer745 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249118 |
| PRKCH | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249123 |
| PRKCH | phosphorylation up-regulates → | GSTP1 PSer185 | phosphorylation up-regulates → | GSTP1 | 15604283 | SIGNOR-276015 |
| PRKCH | phosphorylation up-regulates → | GSTP1 PSer43 | phosphorylation up-regulates → | GSTP1 | 15604283 | SIGNOR-276014 |
| PRKCH | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251634 |
| PRKCH | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276049 |
| PRKCH | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11884598 | SIGNOR-115730 |
| PRKCH | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 19836308 | SIGNOR-188585 |
| PRKCH | phosphorylation up-regulates → | PTPN11 PSer576 | phosphorylation down-regulates ⊣ | PTPN11 | 11781100 | SIGNOR-249137 |
| PRKCH | phosphorylation up-regulates → | PTPN11 PSer595 | phosphorylation down-regulates ⊣ | PTPN11 | 11781100 | SIGNOR-249140 |
| PRKCH | phosphorylation up-regulates → | PRKD1 PSer738 | phosphorylation up-regulates → | PRKD1 | 10197446 | SIGNOR-66730 |
| PRKCH | phosphorylation up-regulates → | PRKD1 PSer742 | phosphorylation up-regulates → | PRKD1 | 10197446 | SIGNOR-66734 |
| PRKCH | phosphorylation up-regulates → | PRKD2 PSer706 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-89423 |
| PRKCH | phosphorylation up-regulates → | PRKD2 PSer710 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-89427 |
| PRKCH | phosphorylation up-regulates → | PRKD2 PSer876 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-89431 |
| PRKCH | phosphorylation up-regulates → | PRKD2 PSer706 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275958 |
| PRKCH | phosphorylation up-regulates → | PRKD2 PSer710 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275957 |
| PRKCH | phosphorylation up-regulates → | PRKD2 PSer876 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275956 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCH | phosphorylation → up-regulates | ANXA1 | SIGNOR-202792 |
| PRKCH | phosphorylation → unknown | ITGB2 | SIGNOR-249118 |
| PRKCH | phosphorylation → unknown | ITGB2 | SIGNOR-249123 |
| PRKCH | phosphorylation → up-regulates activity | GSTP1 | SIGNOR-276015 |
| PRKCH | phosphorylation → up-regulates activity | GSTP1 | SIGNOR-276014 |
| PRKCH | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-261910 |
| PRKCH | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251634 |
| PRKCH | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276049 |
| PRKCH | phosphorylation down-regulates | GSK3A | SIGNOR-115730 |
| PRKCH | phosphorylation down-regulates | GSK3B | SIGNOR-188585 |
| PRKCH | phosphorylation → unknown | PTPN11 | SIGNOR-249137 |
| PRKCH | phosphorylation → unknown | PTPN11 | SIGNOR-249140 |
| PRKCH | phosphorylation → up-regulates | PRKD1 | SIGNOR-66730 |
| PRKCH | phosphorylation → up-regulates | PRKD1 | SIGNOR-66734 |
| PRKCH | phosphorylation → up-regulates | PRKD2 | SIGNOR-89423 |
| PRKCH | phosphorylation → up-regulates | PRKD2 | SIGNOR-89427 |
| PRKCH | phosphorylation → up-regulates | PRKD2 | SIGNOR-89431 |
| PRKCH | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275958 |
| PRKCH | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275957 |
| PRKCH | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275956 |