| Name | MYL9 |
| ID | P24844 |
| Role | substrate |
| Enzymatic Domains |
EF-hand 1 29-64 PROSITE-ProRule
EF-hand 2 98-133 PROSITE-ProRule
EF-hand 3 134-169 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK1 | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 21457715 | SIGNOR-260308 |
| ROCK2 | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 8702756 | SIGNOR-261708 |
| MYLK | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 19851336 | SIGNOR-188801 |
| CIT | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 21457715 | SIGNOR-260306 |
| PTK2 | MYL9 | – | phosphorylation up-regulates activity | 32452639 | SIGNOR-280098 | |
| MYLK | MYL9 | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates | 19851336 | SIGNOR-188797 |
| CDC42BPA | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 19851336 | SIGNOR-188785 |
| ROCK2 | MYL9 | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates activity | 8702756 | SIGNOR-261719 |
| ROCK1 | MYL9 | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates | 8702756 | SIGNOR-43031 |
| ROCK2 | MYL9 | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates activity | 8702756 | SIGNOR-261709 |
| DAPK3 | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 19851336 | SIGNOR-188793 |
| ROCK2 | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 8702756 | SIGNOR-261718 |
| PRKCA | MYL9 | Thr10 | SKRAKAKtTKKRPQR | phosphorylation down-regulates | 22136066 | SIGNOR-191536 |
| CDC42BPA | MYL9 | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates | 19851336 | SIGNOR-188781 |
| ROCK1 | MYL9 | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates activity | 21457715 | SIGNOR-260307 |
| PRKCA | MYL9 | Ser3 | sKRAKAKT | phosphorylation down-regulates | 22136066 | SIGNOR-192792 |
| DAPK3 | MYL9 | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates | 19851336 | SIGNOR-188789 |
| CIT | MYL9 | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates activity | 21457715 | SIGNOR-260305 |
| PRKCA | MYL9 | Ser2 | sSKRAKAK | phosphorylation down-regulates | 22136066 | SIGNOR-177940 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK1 | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 21457715 | SIGNOR-260308 |
| ROCK2 | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-261708 |
| MYLK | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 19851336 | SIGNOR-188801 |
| CIT | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 21457715 | SIGNOR-260306 |
| MYLK | phosphorylation up-regulates → | MYL9 PSer20 | phosphorylation up-regulates → | MYL9 | 19851336 | SIGNOR-188797 |
| CDC42BPA | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 19851336 | SIGNOR-188785 |
| ROCK2 | phosphorylation up-regulates → | MYL9 PSer20 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-261719 |
| ROCK1 | phosphorylation up-regulates → | MYL9 PSer20 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-43031 |
| ROCK2 | phosphorylation up-regulates → | MYL9 PSer20 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-261709 |
| DAPK3 | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 19851336 | SIGNOR-188793 |
| ROCK2 | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-261718 |
| PRKCA | phosphorylation up-regulates → | MYL9 PThr10 | phosphorylation down-regulates ⊣ | MYL9 | 22136066 | SIGNOR-191536 |
| CDC42BPA | phosphorylation up-regulates → | MYL9 PSer20 | phosphorylation up-regulates → | MYL9 | 19851336 | SIGNOR-188781 |
| ROCK1 | phosphorylation up-regulates → | MYL9 PSer20 | phosphorylation up-regulates → | MYL9 | 21457715 | SIGNOR-260307 |
| PRKCA | phosphorylation up-regulates → | MYL9 PSer3 | phosphorylation down-regulates ⊣ | MYL9 | 22136066 | SIGNOR-192792 |
| DAPK3 | phosphorylation up-regulates → | MYL9 PSer20 | phosphorylation up-regulates → | MYL9 | 19851336 | SIGNOR-188789 |
| CIT | phosphorylation up-regulates → | MYL9 PSer20 | phosphorylation up-regulates → | MYL9 | 21457715 | SIGNOR-260305 |
| PRKCA | phosphorylation up-regulates → | MYL9 PSer2 | phosphorylation down-regulates ⊣ | MYL9 | 22136066 | SIGNOR-177940 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ROCK1 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-260308 |
| ROCK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-261708 |
| MYLK | phosphorylation → up-regulates | MYL9 | SIGNOR-188801 |
| CIT | phosphorylation → up-regulates activity | MYL9 | SIGNOR-260306 |
| PTK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-280098 |
| MYLK | phosphorylation → up-regulates | MYL9 | SIGNOR-188797 |
| CDC42BPA | phosphorylation → up-regulates | MYL9 | SIGNOR-188785 |
| ROCK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-261719 |
| ROCK1 | phosphorylation → up-regulates | MYL9 | SIGNOR-43031 |
| ROCK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-261709 |
| DAPK3 | phosphorylation → up-regulates | MYL9 | SIGNOR-188793 |
| ROCK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-261718 |
| PRKCA | phosphorylation down-regulates | MYL9 | SIGNOR-191536 |
| CDC42BPA | phosphorylation → up-regulates | MYL9 | SIGNOR-188781 |
| ROCK1 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-260307 |
| PRKCA | phosphorylation down-regulates | MYL9 | SIGNOR-192792 |
| DAPK3 | phosphorylation → up-regulates | MYL9 | SIGNOR-188789 |
| CIT | phosphorylation → up-regulates activity | MYL9 | SIGNOR-260305 |
| PRKCA | phosphorylation down-regulates | MYL9 | SIGNOR-177940 |