| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK1 | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 21457715 | SIGNOR-260308 |
| ROCK2 | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 8702756 | SIGNOR-261708 |
| MYLK | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 19851336 | SIGNOR-188801 |
| CIT | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 21457715 | SIGNOR-260306 |
| CDC42BPA | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 19851336 | SIGNOR-188785 |
| DAPK3 | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 19851336 | SIGNOR-188793 |
| ROCK2 | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 8702756 | SIGNOR-261718 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK1 | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 21457715 | SIGNOR-260308 |
| ROCK2 | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-261708 |
| MYLK | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 19851336 | SIGNOR-188801 |
| CIT | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 21457715 | SIGNOR-260306 |
| CDC42BPA | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 19851336 | SIGNOR-188785 |
| DAPK3 | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 19851336 | SIGNOR-188793 |
| ROCK2 | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-261718 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ROCK1 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-260308 |
| ROCK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-261708 |
| MYLK | phosphorylation → up-regulates | MYL9 | SIGNOR-188801 |
| CIT | phosphorylation → up-regulates activity | MYL9 | SIGNOR-260306 |
| CDC42BPA | phosphorylation → up-regulates | MYL9 | SIGNOR-188785 |
| DAPK3 | phosphorylation → up-regulates | MYL9 | SIGNOR-188793 |
| ROCK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-261718 |
