| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK12 | POLR2A | Ser1889 | SPTTPKYsPTSPTYS | phosphorylation up-regulates | 22012619 | SIGNOR-176813 |
| CDK9 | POLR2A | Ser1889 | SPTTPKYsPTSPTYS | phosphorylation up-regulates | 24385927 | SIGNOR-203580 |
| CyclinK/CDK12 | POLR2A | Ser1889 | SPTTPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273103 |
| CDK13 | POLR2A | Ser1889 | SPTTPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273053 |
| CyclinK/CDK13 | POLR2A | Ser1889 | SPTTPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273078 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1889 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176813 |
| CDK9 | phosphorylation up-regulates → | POLR2A PSer1889 | phosphorylation up-regulates → | POLR2A | 24385927 | SIGNOR-203580 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1889 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273103 |
| CDK13 | phosphorylation up-regulates → | POLR2A PSer1889 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273053 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1889 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273078 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176813 |
| CDK9 | phosphorylation → up-regulates | POLR2A | SIGNOR-203580 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273103 |
| CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273053 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273078 |
