Entity Details

Name CyclinK/CDK12_Ser1878
ID P24928
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CyclinK/CDK13POLR2ASer1878SPKYSPTsPTYSPTTphosphorylation
up-regulates activity		32917631SIGNOR-273060
CyclinK/CDK12POLR2ASer1878SPKYSPTsPTYSPTTphosphorylation
up-regulates activity		32917631SIGNOR-273085
CDK12POLR2ASer1878SPKYSPTsPTYSPTTphosphorylation
up-regulates activity		22012619SIGNOR-176805
CDK9POLR2ASer1878SPKYSPTsPTYSPTTphosphorylation
up-regulates activity		24385927SIGNOR-203572
CDK13POLR2ASer1878SPKYSPTsPTYSPTTphosphorylation
up-regulates activity		32917631SIGNOR-273035
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CyclinK/CDK13phosphorylation
up-regulates
→
POLR2A
PSer1878		phosphorylation
up-regulates
→		POLR2A32917631SIGNOR-273060
CyclinK/CDK12phosphorylation
up-regulates
→
POLR2A
PSer1878		phosphorylation
up-regulates
→		POLR2A32917631SIGNOR-273085
CDK12phosphorylation
up-regulates
→
POLR2A
PSer1878		phosphorylation
up-regulates
→		POLR2A22012619SIGNOR-176805
CDK9phosphorylation
up-regulates
→
POLR2A
PSer1878		phosphorylation
up-regulates
→		POLR2A24385927SIGNOR-203572
CDK13phosphorylation
up-regulates
→
POLR2A
PSer1878		phosphorylation
up-regulates
→		POLR2A32917631SIGNOR-273035
Regulator Mechanism/Effect Target SIGNOR-ID
CyclinK/CDK13phosphorylation
→
up-regulates activity 		POLR2ASIGNOR-273060
CyclinK/CDK12phosphorylation
→
up-regulates activity 		POLR2ASIGNOR-273085
CDK12phosphorylation
→
up-regulates activity 		POLR2ASIGNOR-176805
CDK9phosphorylation
→
up-regulates activity 		POLR2ASIGNOR-203572
CDK13phosphorylation
→
up-regulates activity 		POLR2ASIGNOR-273035