| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPAP2 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248752 |
| CyclinK/CDK12 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273095 |
| CTDSP1 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248785 |
| CyclinK/CDK13 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273070 |
| CDK13 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273045 |
| CDK9 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | phosphorylation up-regulates | 24385927 | SIGNOR-203532 |
| SSU72 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 15125841 | SIGNOR-248821 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1693 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248752 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1693 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273095 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1693 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248785 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1693 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273070 |
| CDK13 | phosphorylation up-regulates → | POLR2A PSer1693 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273045 |
| CDK9 | phosphorylation up-regulates → | POLR2A PSer1693 | phosphorylation up-regulates → | POLR2A | 24385927 | SIGNOR-203532 |
| SSU72 | dephosphorylation down-regulates ⊣ | POLR2A PSer1693 | dephosphorylation down-regulates ⊣ | POLR2A | 15125841 | SIGNOR-248821 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248752 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273095 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248785 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273070 |
| CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273045 |
| CDK9 | phosphorylation → up-regulates | POLR2A | SIGNOR-203532 |
| SSU72 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248821 |
