Entity Details

Name MAPK1_Ser1871
ID P24928
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK7POLR2ASer1871SPKYSPTsPKYSPTSphosphorylation
down-regulates		14662762SIGNOR-120044
MAPK1POLR2ASer1871SPKYSPTsPKYSPTSphosphorylation
down-regulates		14662762SIGNOR-120132
TFIIHPOLR2ASer1871SPKYSPTsPKYSPTSphosphorylation
down-regulates quantity by destabilization		14662762SIGNOR-269337
MAPK3POLR2ASer1871SPKYSPTsPKYSPTSphosphorylation
down-regulates		14662762SIGNOR-120224
TFIIHPOLR2ASer1871SPKYSPTsPKYSPTSphosphorylation
up-regulates activity		24746699SIGNOR-269368
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK7phosphorylation
up-regulates
→
POLR2A
PSer1871		phosphorylation
down-regulates
⊣		POLR2A14662762SIGNOR-120044
MAPK1phosphorylation
up-regulates
→
POLR2A
PSer1871		phosphorylation
down-regulates
⊣		POLR2A14662762SIGNOR-120132
TFIIHphosphorylation
up-regulates
→
POLR2A
PSer1871		phosphorylation
down-regulates
⊣		POLR2A14662762SIGNOR-269337
MAPK3phosphorylation
up-regulates
→
POLR2A
PSer1871		phosphorylation
down-regulates
⊣		POLR2A14662762SIGNOR-120224
TFIIHphosphorylation
up-regulates
→
POLR2A
PSer1871		phosphorylation
up-regulates
→		POLR2A24746699SIGNOR-269368
Regulator Mechanism/Effect Target SIGNOR-ID
CDK7phosphorylation
img/direct_inhibition.png
down-regulates 		POLR2ASIGNOR-120044
MAPK1phosphorylation
img/direct_inhibition.png
down-regulates 		POLR2ASIGNOR-120132
TFIIHphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		POLR2ASIGNOR-269337
MAPK3phosphorylation
img/direct_inhibition.png
down-regulates 		POLR2ASIGNOR-120224
TFIIHphosphorylation
→
up-regulates activity 		POLR2ASIGNOR-269368