| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK12 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation up-regulates | 22012619 | SIGNOR-176809 |
| CDK13 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273052 |
| CDK7 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation down-regulates | 14662762 | SIGNOR-120048 |
| CyclinK/CDK12 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273102 |
| MAPK3 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation down-regulates | 14662762 | SIGNOR-120228 |
| CyclinK/CDK13 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273077 |
| TFIIH | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269349 |
| CDK9 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation up-regulates | 24385927 | SIGNOR-203576 |
| TFIIH | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269380 |
| MAPK1 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation down-regulates | 14662762 | SIGNOR-120136 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176809 |
| CDK13 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273052 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120048 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273102 |
| MAPK3 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120228 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273077 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269349 |
| CDK9 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation up-regulates → | POLR2A | 24385927 | SIGNOR-203576 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269380 |
| MAPK1 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120136 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176809 |
| CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273052 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120048 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273102 |
| MAPK3 | phosphorylation down-regulates | POLR2A | SIGNOR-120228 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273077 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269349 |
| CDK9 | phosphorylation → up-regulates | POLR2A | SIGNOR-203576 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269380 |
| MAPK1 | phosphorylation down-regulates | POLR2A | SIGNOR-120136 |
