| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSP1 | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248772 |
| MAPK1 | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120096 |
| CDK7 | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120008 |
| MAPK3 | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120188 |
| RPAP2 | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248739 |
| TFIIH | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269333 |
| TFIIH | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269364 |
| SSU72 | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 15125841 | SIGNOR-248808 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1668 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248772 |
| MAPK1 | phosphorylation up-regulates → | POLR2A PSer1668 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120096 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1668 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120008 |
| MAPK3 | phosphorylation up-regulates → | POLR2A PSer1668 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120188 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1668 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248739 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1668 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269333 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1668 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269364 |
| SSU72 | dephosphorylation down-regulates ⊣ | POLR2A PSer1668 | dephosphorylation down-regulates ⊣ | POLR2A | 15125841 | SIGNOR-248808 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248772 |
| MAPK1 | phosphorylation down-regulates | POLR2A | SIGNOR-120096 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120008 |
| MAPK3 | phosphorylation down-regulates | POLR2A | SIGNOR-120188 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248739 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269333 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269364 |
| SSU72 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248808 |
