Entity Details

Name TFIIH_Ser1892
ID P24928
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK1POLR2ASer1892TPKYSPTsPTYSPTSphosphorylation
down-regulates		14662762SIGNOR-120140
CDK7POLR2ASer1892TPKYSPTsPTYSPTSphosphorylation
down-regulates		14662762SIGNOR-120052
TFIIHPOLR2ASer1892TPKYSPTsPTYSPTSphosphorylation
down-regulates quantity by destabilization		14662762SIGNOR-269346
MAPK3POLR2ASer1892TPKYSPTsPTYSPTSphosphorylation
down-regulates		14662762SIGNOR-120232
TFIIHPOLR2ASer1892TPKYSPTsPTYSPTSphosphorylation
up-regulates activity		24746699SIGNOR-269377
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK1phosphorylation
up-regulates
→
POLR2A
PSer1892		phosphorylation
down-regulates
⊣		POLR2A14662762SIGNOR-120140
CDK7phosphorylation
up-regulates
→
POLR2A
PSer1892		phosphorylation
down-regulates
⊣		POLR2A14662762SIGNOR-120052
TFIIHphosphorylation
up-regulates
→
POLR2A
PSer1892		phosphorylation
down-regulates
⊣		POLR2A14662762SIGNOR-269346
MAPK3phosphorylation
up-regulates
→
POLR2A
PSer1892		phosphorylation
down-regulates
⊣		POLR2A14662762SIGNOR-120232
TFIIHphosphorylation
up-regulates
→
POLR2A
PSer1892		phosphorylation
up-regulates
→		POLR2A24746699SIGNOR-269377
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK1phosphorylation
img/direct_inhibition.png
down-regulates 		POLR2ASIGNOR-120140
CDK7phosphorylation
img/direct_inhibition.png
down-regulates 		POLR2ASIGNOR-120052
TFIIHphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		POLR2ASIGNOR-269346
MAPK3phosphorylation
img/direct_inhibition.png
down-regulates 		POLR2ASIGNOR-120232
TFIIHphosphorylation
→
up-regulates activity 		POLR2ASIGNOR-269377