| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | POLR2A | Ser1899 | SPTYSPTsPVYTPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120144 |
| MAPK3 | POLR2A | Ser1899 | SPTYSPTsPVYTPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120236 |
| TFIIH | POLR2A | Ser1899 | SPTYSPTsPVYTPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269347 |
| TFIIH | POLR2A | Ser1899 | SPTYSPTsPVYTPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269378 |
| CDK7 | POLR2A | Ser1899 | SPTYSPTsPVYTPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120056 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | POLR2A PSer1899 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120144 |
| MAPK3 | phosphorylation up-regulates → | POLR2A PSer1899 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120236 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1899 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269347 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1899 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269378 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1899 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120056 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation down-regulates | POLR2A | SIGNOR-120144 |
| MAPK3 | phosphorylation down-regulates | POLR2A | SIGNOR-120236 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269347 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269378 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120056 |
