| Name | CDK2 |
| ID | P24941 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 4-286 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates | 12359725 | SIGNOR-94003 |
| WEE1 | CDK2 | Tyr15 | EKIGEGTyGVVYKAR | phosphorylation down-regulates | 11029659 | SIGNOR-83139 |
| PPM1A | CDK2 | – | dephosphorylation down-regulates activity | 10934208 | SIGNOR-277107 | |
| AKT | CDK2 | Thr39 | LKKIRLDtETEGVPS | phosphorylation up-regulates | 18354084 | SIGNOR-244176 |
| CDC25B | CDK2 | – | dephosphorylation up-regulates activity | 26474275 | SIGNOR-277140 | |
| CDC25A | CDK2 | – | dephosphorylation up-regulates activity | 11154267 | SIGNOR-245449 | |
| PTP4A2 | CDK2 | – | dephosphorylation up-regulates | 14643450 | SIGNOR-119478 | |
| CDC25A | CDK2 | Thr14 | VEKIGEGtYGVVYKA | dephosphorylation up-regulates activity | 10454565 | SIGNOR-248481 |
| CDK7 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates activity | 10085115 | SIGNOR-250768 |
| PTPRG | CDK2 | Tyr15 | EKIGEGTyGVVYKAR | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254695 |
| ERK1/2 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates | 12359725 | SIGNOR-244614 |
| CAK complex | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates activity | 10085115 | SIGNOR-269330 |
| LYN | CDK2 | Tyr15 | EKIGEGTyGVVYKAR | phosphorylation down-regulates activity | 8806683 | SIGNOR-279204 |
| PPM1B | CDK2 | – | dephosphorylation down-regulates activity | 20538721 | SIGNOR-277153 | |
| CDC25A | CDK2 | Tyr15 | EKIGEGTyGVVYKAR | dephosphorylation up-regulates activity | 10454565 | SIGNOR-248482 |
| CDC25A | CDK2 | Thr14 | VEKIGEGtYGVVYKA | dephosphorylation up-regulates | 22263797 | SIGNOR-195521 |
| CDC25A | CDK2 | Thr14 | VEKIGEGtYGVVYKA | dephosphorylation up-regulates | 12411508 | SIGNOR-95252 |
| CDKN3 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | dephosphorylation down-regulates activity | 11463386 | SIGNOR-248724 |
| CDK2 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates | 17361108 | SIGNOR-153636 |
| AKT1 | CDK2 | Thr39 | LKKIRLDtETEGVPS | phosphorylation up-regulates | 18354084 | SIGNOR-178058 |
| CDK20 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates | 14597612 | SIGNOR-118986 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 12359725 | SIGNOR-94003 |
| WEE1 | phosphorylation up-regulates → | CDK2 PTyr15 | phosphorylation down-regulates ⊣ | CDK2 | 11029659 | SIGNOR-83139 |
| AKT | phosphorylation up-regulates → | CDK2 PThr39 | phosphorylation up-regulates → | CDK2 | 18354084 | SIGNOR-244176 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK2 PThr14 | dephosphorylation down-regulates ⊣ | CDK2 | 10454565 | SIGNOR-248481 |
| CDK7 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 10085115 | SIGNOR-250768 |
| PTPRG | dephosphorylation down-regulates ⊣ | CDK2 PTyr15 | dephosphorylation up-regulates → | CDK2 | 25624455 | SIGNOR-254695 |
| ERK1/2 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 12359725 | SIGNOR-244614 |
| CAK complex | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 10085115 | SIGNOR-269330 |
| LYN | phosphorylation up-regulates → | CDK2 PTyr15 | phosphorylation down-regulates ⊣ | CDK2 | 8806683 | SIGNOR-279204 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK2 PTyr15 | dephosphorylation down-regulates ⊣ | CDK2 | 10454565 | SIGNOR-248482 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK2 PThr14 | dephosphorylation down-regulates ⊣ | CDK2 | 22263797 | SIGNOR-195521 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK2 PThr14 | dephosphorylation down-regulates ⊣ | CDK2 | 12411508 | SIGNOR-95252 |
| CDKN3 | dephosphorylation down-regulates ⊣ | CDK2 PThr160 | dephosphorylation up-regulates → | CDK2 | 11463386 | SIGNOR-248724 |
| CDK2 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 17361108 | SIGNOR-153636 |
| AKT1 | phosphorylation up-regulates → | CDK2 PThr39 | phosphorylation up-regulates → | CDK2 | 18354084 | SIGNOR-178058 |
| CDK20 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 14597612 | SIGNOR-118986 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates | CDK2 | SIGNOR-94003 |
| WEE1 | phosphorylation down-regulates | CDK2 | SIGNOR-83139 |
| PPM1A | dephosphorylation → down-regulates activity | CDK2 | SIGNOR-277107 |
| AKT | phosphorylation → up-regulates | CDK2 | SIGNOR-244176 |
| CDC25B | dephosphorylation → up-regulates activity | CDK2 | SIGNOR-277140 |
| CDC25A | dephosphorylation → up-regulates activity | CDK2 | SIGNOR-245449 |
| PTP4A2 | dephosphorylation → up-regulates | CDK2 | SIGNOR-119478 |
| CDC25A | dephosphorylation → up-regulates activity | CDK2 | SIGNOR-248481 |
| CDK7 | phosphorylation → up-regulates activity | CDK2 | SIGNOR-250768 |
| PTPRG | dephosphorylation → down-regulates activity | CDK2 | SIGNOR-254695 |
| ERK1/2 | phosphorylation → up-regulates | CDK2 | SIGNOR-244614 |
| CAK complex | phosphorylation → up-regulates activity | CDK2 | SIGNOR-269330 |
| LYN | phosphorylation → down-regulates activity | CDK2 | SIGNOR-279204 |
| PPM1B | dephosphorylation → down-regulates activity | CDK2 | SIGNOR-277153 |
| CDC25A | dephosphorylation → up-regulates activity | CDK2 | SIGNOR-248482 |
| CDC25A | dephosphorylation → up-regulates | CDK2 | SIGNOR-195521 |
| CDC25A | dephosphorylation → up-regulates | CDK2 | SIGNOR-95252 |
| CDKN3 | dephosphorylation → down-regulates activity | CDK2 | SIGNOR-248724 |
| CDK2 | phosphorylation → up-regulates | CDK2 | SIGNOR-153636 |
| AKT1 | phosphorylation → up-regulates | CDK2 | SIGNOR-178058 |
| CDK20 | phosphorylation → up-regulates | CDK2 | SIGNOR-118986 |