| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC25A | CDK2 | Thr14 | VEKIGEGtYGVVYKA | dephosphorylation up-regulates | 22263797 | SIGNOR-195521 |
| CDC25A | CDK2 | Thr14 | VEKIGEGtYGVVYKA | dephosphorylation up-regulates | 12411508 | SIGNOR-95252 |
| CDC25A | CDK2 | Thr14 | VEKIGEGtYGVVYKA | dephosphorylation up-regulates activity | 10454565 | SIGNOR-248481 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC25A | dephosphorylation down-regulates ⊣ | CDK2 PThr14 | dephosphorylation down-regulates ⊣ | CDK2 | 22263797 | SIGNOR-195521 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK2 PThr14 | dephosphorylation down-regulates ⊣ | CDK2 | 12411508 | SIGNOR-95252 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK2 PThr14 | dephosphorylation down-regulates ⊣ | CDK2 | 10454565 | SIGNOR-248481 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC25A | dephosphorylation → up-regulates | CDK2 | SIGNOR-195521 |
| CDC25A | dephosphorylation → up-regulates | CDK2 | SIGNOR-95252 |
| CDC25A | dephosphorylation → up-regulates activity | CDK2 | SIGNOR-248481 |
