| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDKN3 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | dephosphorylation down-regulates activity | 11463386 | SIGNOR-248724 |
| CDK2 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates | 17361108 | SIGNOR-153636 |
| CDK20 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates | 14597612 | SIGNOR-118986 |
| MAPK1 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates | 12359725 | SIGNOR-94003 |
| CDK7 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates activity | 10085115 | SIGNOR-250768 |
| ERK1/2 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates | 12359725 | SIGNOR-244614 |
| CAK complex | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates activity | 10085115 | SIGNOR-269330 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDKN3 | dephosphorylation down-regulates ⊣ | CDK2 PThr160 | dephosphorylation up-regulates → | CDK2 | 11463386 | SIGNOR-248724 |
| CDK2 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 17361108 | SIGNOR-153636 |
| CDK20 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 14597612 | SIGNOR-118986 |
| MAPK1 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 12359725 | SIGNOR-94003 |
| CDK7 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 10085115 | SIGNOR-250768 |
| ERK1/2 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 12359725 | SIGNOR-244614 |
| CAK complex | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 10085115 | SIGNOR-269330 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDKN3 | dephosphorylation → down-regulates activity | CDK2 | SIGNOR-248724 |
| CDK2 | phosphorylation → up-regulates | CDK2 | SIGNOR-153636 |
| CDK20 | phosphorylation → up-regulates | CDK2 | SIGNOR-118986 |
| MAPK1 | phosphorylation → up-regulates | CDK2 | SIGNOR-94003 |
| CDK7 | phosphorylation → up-regulates activity | CDK2 | SIGNOR-250768 |
| ERK1/2 | phosphorylation → up-regulates | CDK2 | SIGNOR-244614 |
| CAK complex | phosphorylation → up-regulates activity | CDK2 | SIGNOR-269330 |
