| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC25A | CDK2 | Tyr15 | EKIGEGTyGVVYKAR | dephosphorylation up-regulates activity | 10454565 | SIGNOR-248482 |
| LYN | CDK2 | Tyr15 | EKIGEGTyGVVYKAR | phosphorylation down-regulates activity | 8806683 | SIGNOR-279204 |
| PTPRG | CDK2 | Tyr15 | EKIGEGTyGVVYKAR | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254695 |
| WEE1 | CDK2 | Tyr15 | EKIGEGTyGVVYKAR | phosphorylation down-regulates | 11029659 | SIGNOR-83139 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC25A | dephosphorylation down-regulates ⊣ | CDK2 PTyr15 | dephosphorylation down-regulates ⊣ | CDK2 | 10454565 | SIGNOR-248482 |
| LYN | phosphorylation up-regulates → | CDK2 PTyr15 | phosphorylation down-regulates ⊣ | CDK2 | 8806683 | SIGNOR-279204 |
| PTPRG | dephosphorylation down-regulates ⊣ | CDK2 PTyr15 | dephosphorylation up-regulates → | CDK2 | 25624455 | SIGNOR-254695 |
| WEE1 | phosphorylation up-regulates → | CDK2 PTyr15 | phosphorylation down-regulates ⊣ | CDK2 | 11029659 | SIGNOR-83139 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC25A | dephosphorylation → up-regulates activity | CDK2 | SIGNOR-248482 |
| LYN | phosphorylation → down-regulates activity | CDK2 | SIGNOR-279204 |
| PTPRG | dephosphorylation → down-regulates activity | CDK2 | SIGNOR-254695 |
| WEE1 | phosphorylation down-regulates | CDK2 | SIGNOR-83139 |
