| Name | GRK2 |
| ID | P25098 |
| Role | kinase |
| Enzymatic Domains |
RGS 54-175 PROSITE-ProRule
Protein kinase 191-453 PROSITE-ProRule
AGC-kinase C-terminal 454-521 PROSITE-ProRule
PH 558-652 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | OPRM1 | Ser357 | REFCIPTsSNIEQQN | phosphorylation down-regulates activity | 12123746 | SIGNOR-251458 |
| GRK2 | MAPK14 | Thr123 | IVKCQKLtDDHVQFL | phosphorylation down-regulates | 17055984 | SIGNOR-150152 |
| GRK2 | GPR17 | – | phosphorylation down-regulates activity | 24613411 | SIGNOR-279999 | |
| GRK2 | RAPGEF3 | Ser108 | S-->L | phosphorylation down-regulates activity | 28580839 | SIGNOR-280001 |
| GRK2 | RPLP2 | Ser105 | KKEESEEsDDDMGFG | phosphorylation up-regulates | 12379128 | SIGNOR-94258 |
| GRK2 | OPRD1 | Ser363 | RVTACTPsDGPGGGA | phosphorylation down-regulates activity | 11040053 | SIGNOR-249660 |
| GRK2 | RPLP2 | Ser102 | KDEKKEEsEESDDDM | phosphorylation up-regulates | 12379128 | SIGNOR-94254 |
| GRK2 | NTSR1 | – | phosphorylation up-regulates activity | 26120872 | SIGNOR-278280 | |
| GRK2 | BDKRB2 | Ser373 | SMGTLRTsISVERQI | phosphorylation down-regulates activity | 11517230 | SIGNOR-251445 |
| GRK2 | STK3 | Ser316 | LEEEEENsDEDELDS | phosphorylation up-regulates activity | 23904266 | SIGNOR-278206 |
| GRK2 | FPR1 | Thr336 | TQTSDTAtNSTLPSA | phosphorylation down-regulates activity | 7836371 | SIGNOR-249686 |
| GRK2 | OXTR | – | phosphorylation down-regulates activity | 16179383 | SIGNOR-270329 | |
| GRK2 | MC4R | Ser329 | LGGLCDLsSRY | phosphorylation down-regulates activity | 12639913 | SIGNOR-251453 |
| GRK2 | ADRA2A | Ser314 | DLEESSSsDHAERPP | phosphorylation down-regulates activity | 7876239 | SIGNOR-251443 |
| GRK2 | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15843435 | SIGNOR-135622 |
| GRK2 | SLC9A5 | Ser711 | EEEEESDsSETEKED | phosphorylation down-regulates activity | 21296876 | SIGNOR-275501 |
| GRK2 | PDC | – | phosphorylation down-regulates activity | 10884381 | SIGNOR-279411 | |
| GRK2 | ADIPOR1 | – | phosphorylation down-regulates activity | 25696921 | SIGNOR-279463 | |
| GRK2 | PDE6G | Thr62 | PGMEGLGtDITVICP | phosphorylation up-regulates activity | 12624098 | SIGNOR-247823 |
| GRK2 | PDE6G | Thr62 | PGMEGLGtDITVICP | phosphorylation up-regulates activity | 11502744 | SIGNOR-251459 |
| GRK2 | SLC9A5 | Ser702 | AVILTVEsEEEEEES | phosphorylation down-regulates activity | 21296876 | SIGNOR-275503 |
| GRK2 | SMO | – | phosphorylation up-regulates | 21695114 | SIGNOR-174539 | |
| GRK2 | ADRA2A | Ser313 | LDLEESSsSDHAERP | phosphorylation down-regulates activity | 7876239 | SIGNOR-251442 |
| GRK2 | FPR1 | Thr329 | RALTEDStQTSDTAT | phosphorylation down-regulates activity | 7836371 | SIGNOR-249664 |
| GRK2 | SLC9A5 | Thr714 | EESDSSEtEKEDDEG | phosphorylation down-regulates activity | 21296876 | SIGNOR-275502 |
| GRK2 | TP53INP2 | – | phosphorylation down-regulates activity | 27568556 | SIGNOR-279739 | |
| GRK2 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 10852916 | SIGNOR-78333 |
| GRK2 | CLTB | Ser205 | LCDFNPKsSKQCKDV | phosphorylation unknown | 22704991 | SIGNOR-197873 |
| GRK2 | SLC9A5 | Ser709 | SEEEEEEsDSSETEK | phosphorylation down-regulates activity | 21296876 | SIGNOR-275504 |
| GRK2 | FPR1 | Thr339 | SDTATNStLPSAEVE | phosphorylation down-regulates activity | 7836371 | SIGNOR-251452 |
| GRK2 | CD36 | – | phosphorylation down-regulates quantity by destabilization | 30171848 | SIGNOR-279524 | |
| GRK2 | OPRD1 | Thr358 | ATARERVtACTPSDG | phosphorylation down-regulates activity | 11040053 | SIGNOR-251457 |
| GRK2 | ADIPOR1 | Ser205 | EKVSRTFsKLDYSGI | phosphorylation down-regulates quantity by destabilization | 35611695 | SIGNOR-277594 |
| GRK2 | PDGFRB | Ser1104 | PRAEAEDsFL | phosphorylation down-regulates activity | 15271984 | SIGNOR-278379 |
| GRK2 | STK3 | Ser18 | LKKLSEDsLTKQPEE | phosphorylation up-regulates activity | 23904266 | SIGNOR-278207 |
| GRK2 | ADRA2A | Ser311 | DALDLEEsSSSDHAE | phosphorylation down-regulates activity | 7876239 | SIGNOR-251440 |
| GRK2 | SLC9A5 | Ser712 | EEEESDSsETEKEDD | phosphorylation down-regulates activity | 21296876 | SIGNOR-275500 |
| GRK2 | MC4R | Ser330 | GGLCDLSsRY | phosphorylation down-regulates activity | 12639913 | SIGNOR-249673 |
| GRK2 | ADRA2A | Ser312 | ALDLEESsSSDHAER | phosphorylation down-regulates activity | 7876239 | SIGNOR-251441 |
| GRK2 | TBXA2R | Ser239 | AQQRPRDsEVEMMAQ | phosphorylation down-regulates activity | 16956790 | SIGNOR-274088 |
| GRK2 | PDCL | – | phosphorylation down-regulates activity | 10884381 | SIGNOR-279178 | |
| GRK2 | C3AR1 | – | phosphorylation down-regulates activity | 21799898 | SIGNOR-279044 | |
| GRK2 | SMO | – | phosphorylation up-regulates | 15618519 | SIGNOR-132669 | |
| GRK2 | FPR1 | Ser332 | TEDSTQTsDTATNST | phosphorylation down-regulates activity | 7836371 | SIGNOR-249680 |
| GRK2 | FPR1 | Ser328 | ERALTEDsTQTSDTA | phosphorylation down-regulates activity | 7836371 | SIGNOR-247763 |
| GRK2 | FPR1 | Thr331 | LTEDSTQtSDTATNS | phosphorylation down-regulates activity | 7836371 | SIGNOR-249676 |
| GRK2 | BDKRB2 | Ser366 | EPIQMENsMGTLRTS | phosphorylation down-regulates activity | 11517230 | SIGNOR-251444 |
| GRK2 | FPR1 | Thr334 | DSTQTSDtATNSTLP | phosphorylation down-regulates activity | 7836371 | SIGNOR-251451 |
| GRK2 | IGF1R | Ser1278 | EPGFREVsFYYSEEN | phosphorylation down-regulates quantity by destabilization | 22509025 | SIGNOR-276413 |
| GRK2 | OPRM1 | Thr356 | FREFCIPtSSNIEQQ | phosphorylation down-regulates activity | 12123746 | SIGNOR-247782 |
| GRK2 | SNCG | Ser124 | EVAEEAQsGGD | phosphorylation down-regulates activity | 10852916 | SIGNOR-251204 |
| GRK2 | MC4R | Thr312 | RSQELRKtFKEIICC | phosphorylation down-regulates activity | 12639913 | SIGNOR-247770 |
| GRK2 | SMO | – | phosphorylation up-regulates | 23074268 | SIGNOR-199104 | |
| GRK2 | TBXA2R | Ser357 | RLPGSSDsRASASRA | phosphorylation down-regulates activity | 16956790 | SIGNOR-274089 |
| GRK2 | BDKRB2 | Ser375 | GTLRTSIsVERQIHK | phosphorylation down-regulates activity | 11517230 | SIGNOR-251446 |
| GRK2 | OPRM1 | Ser358 | EFCIPTSsNIEQQNS | phosphorylation down-regulates activity | 12123746 | SIGNOR-249661 |
| GRK2 | CXCR2 | – | phosphorylation down-regulates activity | 22634615 | SIGNOR-260647 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | phosphorylation up-regulates → | OPRM1 PSer357 | phosphorylation down-regulates ⊣ | OPRM1 | 12123746 | SIGNOR-251458 |
| GRK2 | phosphorylation up-regulates → | MAPK14 PThr123 | phosphorylation down-regulates ⊣ | MAPK14 | 17055984 | SIGNOR-150152 |
| GRK2 | phosphorylation up-regulates → | RAPGEF3 PSer108 | phosphorylation down-regulates ⊣ | RAPGEF3 | 28580839 | SIGNOR-280001 |
| GRK2 | phosphorylation up-regulates → | RPLP2 PSer105 | phosphorylation up-regulates → | RPLP2 | 12379128 | SIGNOR-94258 |
| GRK2 | phosphorylation up-regulates → | OPRD1 PSer363 | phosphorylation down-regulates ⊣ | OPRD1 | 11040053 | SIGNOR-249660 |
| GRK2 | phosphorylation up-regulates → | RPLP2 PSer102 | phosphorylation up-regulates → | RPLP2 | 12379128 | SIGNOR-94254 |
| GRK2 | phosphorylation up-regulates → | BDKRB2 PSer373 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251445 |
| GRK2 | phosphorylation up-regulates → | STK3 PSer316 | phosphorylation up-regulates → | STK3 | 23904266 | SIGNOR-278206 |
| GRK2 | phosphorylation up-regulates → | FPR1 PThr336 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-249686 |
| GRK2 | phosphorylation up-regulates → | MC4R PSer329 | phosphorylation down-regulates ⊣ | MC4R | 12639913 | SIGNOR-251453 |
| GRK2 | phosphorylation up-regulates → | ADRA2A PSer314 | phosphorylation down-regulates ⊣ | ADRA2A | 7876239 | SIGNOR-251443 |
| GRK2 | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15843435 | SIGNOR-135622 |
| GRK2 | phosphorylation up-regulates → | SLC9A5 PSer711 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-275501 |
| GRK2 | phosphorylation up-regulates → | PDE6G PThr62 | phosphorylation up-regulates → | PDE6G | 12624098 | SIGNOR-247823 |
| GRK2 | phosphorylation up-regulates → | PDE6G PThr62 | phosphorylation up-regulates → | PDE6G | 11502744 | SIGNOR-251459 |
| GRK2 | phosphorylation up-regulates → | SLC9A5 PSer702 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-275503 |
| GRK2 | phosphorylation up-regulates → | ADRA2A PSer313 | phosphorylation down-regulates ⊣ | ADRA2A | 7876239 | SIGNOR-251442 |
| GRK2 | phosphorylation up-regulates → | FPR1 PThr329 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-249664 |
| GRK2 | phosphorylation up-regulates → | SLC9A5 PThr714 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-275502 |
| GRK2 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 10852916 | SIGNOR-78333 |
| GRK2 | phosphorylation up-regulates → | CLTB PSer205 | phosphorylation down-regulates ⊣ | CLTB | 22704991 | SIGNOR-197873 |
| GRK2 | phosphorylation up-regulates → | SLC9A5 PSer709 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-275504 |
| GRK2 | phosphorylation up-regulates → | FPR1 PThr339 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-251452 |
| GRK2 | phosphorylation up-regulates → | OPRD1 PThr358 | phosphorylation down-regulates ⊣ | OPRD1 | 11040053 | SIGNOR-251457 |
| GRK2 | phosphorylation up-regulates → | ADIPOR1 PSer205 | phosphorylation down-regulates ⊣ | ADIPOR1 | 35611695 | SIGNOR-277594 |
| GRK2 | phosphorylation up-regulates → | PDGFRB PSer1104 | phosphorylation down-regulates ⊣ | PDGFRB | 15271984 | SIGNOR-278379 |
| GRK2 | phosphorylation up-regulates → | STK3 PSer18 | phosphorylation up-regulates → | STK3 | 23904266 | SIGNOR-278207 |
| GRK2 | phosphorylation up-regulates → | ADRA2A PSer311 | phosphorylation down-regulates ⊣ | ADRA2A | 7876239 | SIGNOR-251440 |
| GRK2 | phosphorylation up-regulates → | SLC9A5 PSer712 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-275500 |
| GRK2 | phosphorylation up-regulates → | MC4R PSer330 | phosphorylation down-regulates ⊣ | MC4R | 12639913 | SIGNOR-249673 |
| GRK2 | phosphorylation up-regulates → | ADRA2A PSer312 | phosphorylation down-regulates ⊣ | ADRA2A | 7876239 | SIGNOR-251441 |
| GRK2 | phosphorylation up-regulates → | TBXA2R PSer239 | phosphorylation down-regulates ⊣ | TBXA2R | 16956790 | SIGNOR-274088 |
| GRK2 | phosphorylation up-regulates → | FPR1 PSer332 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-249680 |
| GRK2 | phosphorylation up-regulates → | FPR1 PSer328 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-247763 |
| GRK2 | phosphorylation up-regulates → | FPR1 PThr331 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-249676 |
| GRK2 | phosphorylation up-regulates → | BDKRB2 PSer366 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251444 |
| GRK2 | phosphorylation up-regulates → | FPR1 PThr334 | phosphorylation down-regulates ⊣ | FPR1 | 7836371 | SIGNOR-251451 |
| GRK2 | phosphorylation up-regulates → | IGF1R PSer1278 | phosphorylation down-regulates ⊣ | IGF1R | 22509025 | SIGNOR-276413 |
| GRK2 | phosphorylation up-regulates → | OPRM1 PThr356 | phosphorylation down-regulates ⊣ | OPRM1 | 12123746 | SIGNOR-247782 |
| GRK2 | phosphorylation up-regulates → | SNCG PSer124 | phosphorylation down-regulates ⊣ | SNCG | 10852916 | SIGNOR-251204 |
| GRK2 | phosphorylation up-regulates → | MC4R PThr312 | phosphorylation down-regulates ⊣ | MC4R | 12639913 | SIGNOR-247770 |
| GRK2 | phosphorylation up-regulates → | TBXA2R PSer357 | phosphorylation down-regulates ⊣ | TBXA2R | 16956790 | SIGNOR-274089 |
| GRK2 | phosphorylation up-regulates → | BDKRB2 PSer375 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251446 |
| GRK2 | phosphorylation up-regulates → | OPRM1 PSer358 | phosphorylation down-regulates ⊣ | OPRM1 | 12123746 | SIGNOR-249661 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK2 | phosphorylation → down-regulates activity | OPRM1 | SIGNOR-251458 |
| GRK2 | phosphorylation down-regulates | MAPK14 | SIGNOR-150152 |
| GRK2 | phosphorylation → down-regulates activity | GPR17 | SIGNOR-279999 |
| GRK2 | phosphorylation → down-regulates activity | RAPGEF3 | SIGNOR-280001 |
| GRK2 | phosphorylation → up-regulates | RPLP2 | SIGNOR-94258 |
| GRK2 | phosphorylation → down-regulates activity | OPRD1 | SIGNOR-249660 |
| GRK2 | phosphorylation → up-regulates | RPLP2 | SIGNOR-94254 |
| GRK2 | phosphorylation → up-regulates activity | NTSR1 | SIGNOR-278280 |
| GRK2 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251445 |
| GRK2 | phosphorylation → up-regulates activity | STK3 | SIGNOR-278206 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-249686 |
| GRK2 | phosphorylation → down-regulates activity | OXTR | SIGNOR-270329 |
| GRK2 | phosphorylation → down-regulates activity | MC4R | SIGNOR-251453 |
| GRK2 | phosphorylation → down-regulates activity | ADRA2A | SIGNOR-251443 |
| GRK2 | phosphorylation → up-regulates | EZR | SIGNOR-135622 |
| GRK2 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-275501 |
| GRK2 | phosphorylation → down-regulates activity | PDC | SIGNOR-279411 |
| GRK2 | phosphorylation → down-regulates activity | ADIPOR1 | SIGNOR-279463 |
| GRK2 | phosphorylation → up-regulates activity | PDE6G | SIGNOR-247823 |
| GRK2 | phosphorylation → up-regulates activity | PDE6G | SIGNOR-251459 |
| GRK2 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-275503 |
| GRK2 | phosphorylation → up-regulates | SMO | SIGNOR-174539 |
| GRK2 | phosphorylation → down-regulates activity | ADRA2A | SIGNOR-251442 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-249664 |
| GRK2 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-275502 |
| GRK2 | phosphorylation → down-regulates activity | TP53INP2 | SIGNOR-279739 |
| GRK2 | phosphorylation → down-regulates activity | SNCA | SIGNOR-78333 |
| GRK2 | phosphorylation → unknown | CLTB | SIGNOR-197873 |
| GRK2 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-275504 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-251452 |
| GRK2 | phosphorylation down-regulates quantity by destabilization | CD36 | SIGNOR-279524 |
| GRK2 | phosphorylation → down-regulates activity | OPRD1 | SIGNOR-251457 |
| GRK2 | phosphorylation down-regulates quantity by destabilization | ADIPOR1 | SIGNOR-277594 |
| GRK2 | phosphorylation → down-regulates activity | PDGFRB | SIGNOR-278379 |
| GRK2 | phosphorylation → up-regulates activity | STK3 | SIGNOR-278207 |
| GRK2 | phosphorylation → down-regulates activity | ADRA2A | SIGNOR-251440 |
| GRK2 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-275500 |
| GRK2 | phosphorylation → down-regulates activity | MC4R | SIGNOR-249673 |
| GRK2 | phosphorylation → down-regulates activity | ADRA2A | SIGNOR-251441 |
| GRK2 | phosphorylation → down-regulates activity | TBXA2R | SIGNOR-274088 |
| GRK2 | phosphorylation → down-regulates activity | PDCL | SIGNOR-279178 |
| GRK2 | phosphorylation → down-regulates activity | C3AR1 | SIGNOR-279044 |
| GRK2 | phosphorylation → up-regulates | SMO | SIGNOR-132669 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-249680 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-247763 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-249676 |
| GRK2 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251444 |
| GRK2 | phosphorylation → down-regulates activity | FPR1 | SIGNOR-251451 |
| GRK2 | phosphorylation down-regulates quantity by destabilization | IGF1R | SIGNOR-276413 |
| GRK2 | phosphorylation → down-regulates activity | OPRM1 | SIGNOR-247782 |
| GRK2 | phosphorylation → down-regulates activity | SNCG | SIGNOR-251204 |
| GRK2 | phosphorylation → down-regulates activity | MC4R | SIGNOR-247770 |
| GRK2 | phosphorylation → up-regulates | SMO | SIGNOR-199104 |
| GRK2 | phosphorylation → down-regulates activity | TBXA2R | SIGNOR-274089 |
| GRK2 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251446 |
| GRK2 | phosphorylation → down-regulates activity | OPRM1 | SIGNOR-249661 |
| GRK2 | phosphorylation → down-regulates activity | CXCR2 | SIGNOR-260647 |