| Name | GRK2 |
| ID | P25098 |
| Role | substrate |
| Enzymatic Domains |
RGS 54-175 PROSITE-ProRule
Protein kinase 191-453 PROSITE-ProRule
AGC-kinase C-terminal 454-521 PROSITE-ProRule
PH 558-652 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | GRK2 | Ser29 | ATPAARAsKKILLPE | phosphorylation up-regulates activity | 11042191 | SIGNOR-249059 |
| SRC | GRK2 | Tyr92 | FYEEIKKyEKLETEE | phosphorylation up-regulates activity | 16725308 | SIGNOR-266293 |
| PRKCG | GRK2 | Ser29 | ATPAARAsKKILLPE | phosphorylation up-regulates activity | 11042191 | SIGNOR-249060 |
| PRKCA | GRK2 | Ser29 | ATPAARAsKKILLPE | phosphorylation up-regulates activity | 11042191 | SIGNOR-249058 |
| EGFR | GRK2 | Tyr13 | AVLADVSyLMAMEKS | phosphorylation up-regulates activity | 23904266 | SIGNOR-279368 |
| MAPK3 | GRK2 | Ser670 | KMKNKPRsPVVELSK | phosphorylation down-regulates | 10574913 | SIGNOR-72582 |
| CDK2 | GRK2 | Ser670 | KMKNKPRsPVVELSK | phosphorylation down-regulates | 20080565 | SIGNOR-163279 |
| SRC | GRK2 | Tyr92 | FYEEIKKyEKLETEE | phosphorylation up-regulates activity | 16725308 | SIGNOR-266305 |
| PRKACA | GRK2 | Ser685 | VPLVQRGsANGL | phosphorylation up-regulates activity | 11278469 | SIGNOR-250334 |
| PRKCG | GRK2 | Ser29 | ATPAARAsKKILLPE | phosphorylation up-regulates | 11042191 | SIGNOR-83231 |
| SRC | GRK2 | Tyr86 | ARPLVEFyEEIKKYE | phosphorylation up-regulates activity | 16725308 | SIGNOR-266306 |
| PDGFRB | GRK2 | – | phosphorylation up-regulates activity | 15994317 | SIGNOR-278972 | |
| SRC | GRK2 | Tyr13 | AVLADVSyLMAMEKS | phosphorylation up-regulates activity | 16725308 | SIGNOR-266307 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | phosphorylation up-regulates → | GRK2 PSer29 | phosphorylation up-regulates → | GRK2 | 11042191 | SIGNOR-249059 |
| SRC | phosphorylation up-regulates → | GRK2 PTyr92 | phosphorylation up-regulates → | GRK2 | 16725308 | SIGNOR-266293 |
| PRKCG | phosphorylation up-regulates → | GRK2 PSer29 | phosphorylation up-regulates → | GRK2 | 11042191 | SIGNOR-249060 |
| PRKCA | phosphorylation up-regulates → | GRK2 PSer29 | phosphorylation up-regulates → | GRK2 | 11042191 | SIGNOR-249058 |
| EGFR | phosphorylation up-regulates → | GRK2 PTyr13 | phosphorylation up-regulates → | GRK2 | 23904266 | SIGNOR-279368 |
| MAPK3 | phosphorylation up-regulates → | GRK2 PSer670 | phosphorylation down-regulates ⊣ | GRK2 | 10574913 | SIGNOR-72582 |
| CDK2 | phosphorylation up-regulates → | GRK2 PSer670 | phosphorylation down-regulates ⊣ | GRK2 | 20080565 | SIGNOR-163279 |
| SRC | phosphorylation up-regulates → | GRK2 PTyr92 | phosphorylation up-regulates → | GRK2 | 16725308 | SIGNOR-266305 |
| PRKACA | phosphorylation up-regulates → | GRK2 PSer685 | phosphorylation up-regulates → | GRK2 | 11278469 | SIGNOR-250334 |
| PRKCG | phosphorylation up-regulates → | GRK2 PSer29 | phosphorylation up-regulates → | GRK2 | 11042191 | SIGNOR-83231 |
| SRC | phosphorylation up-regulates → | GRK2 PTyr86 | phosphorylation up-regulates → | GRK2 | 16725308 | SIGNOR-266306 |
| SRC | phosphorylation up-regulates → | GRK2 PTyr13 | phosphorylation up-regulates → | GRK2 | 16725308 | SIGNOR-266307 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCD | phosphorylation → up-regulates activity | GRK2 | SIGNOR-249059 |
| SRC | phosphorylation → up-regulates activity | GRK2 | SIGNOR-266293 |
| PRKCG | phosphorylation → up-regulates activity | GRK2 | SIGNOR-249060 |
| PRKCA | phosphorylation → up-regulates activity | GRK2 | SIGNOR-249058 |
| EGFR | phosphorylation → up-regulates activity | GRK2 | SIGNOR-279368 |
| MAPK3 | phosphorylation down-regulates | GRK2 | SIGNOR-72582 |
| CDK2 | phosphorylation down-regulates | GRK2 | SIGNOR-163279 |
| SRC | phosphorylation → up-regulates activity | GRK2 | SIGNOR-266305 |
| PRKACA | phosphorylation → up-regulates activity | GRK2 | SIGNOR-250334 |
| PRKCG | phosphorylation → up-regulates | GRK2 | SIGNOR-83231 |
| SRC | phosphorylation → up-regulates activity | GRK2 | SIGNOR-266306 |
| PDGFRB | phosphorylation → up-regulates activity | GRK2 | SIGNOR-278972 |
| SRC | phosphorylation → up-regulates activity | GRK2 | SIGNOR-266307 |