| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | GRK2 | Ser670 | KMKNKPRsPVVELSK | phosphorylation down-regulates | 10574913 | SIGNOR-72582 |
| CDK2 | GRK2 | Ser670 | KMKNKPRsPVVELSK | phosphorylation down-regulates | 20080565 | SIGNOR-163279 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | GRK2 PSer670 | phosphorylation down-regulates ⊣ | GRK2 | 10574913 | SIGNOR-72582 |
| CDK2 | phosphorylation up-regulates → | GRK2 PSer670 | phosphorylation down-regulates ⊣ | GRK2 | 20080565 | SIGNOR-163279 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation![]() down-regulates | GRK2 | SIGNOR-72582 |
| CDK2 | phosphorylation![]() down-regulates | GRK2 | SIGNOR-163279 |